5466-47-7

Usage

Class

Naphthotriazole derivatives
Belongs to a group of chemical compounds derived from the parent compound naphthotriazole.

Appearance

Yellow crystalline solid
The compound's physical form, which is characterized by its yellow color and crystalline structure.

Use as a fluorescent probe

Detecting reactive oxygen species in biological systems
The compound's ability to emit light upon interaction with reactive oxygen species, making it a valuable tool for studying these species in biological systems.

Potential application

Photosensitizer in photodynamic therapy for cancer treatment
The compound's ability to absorb light and generate reactive oxygen species, which can be used to selectively kill cancer cells in the presence of light.

Versatility and value

Biochemistry, medicine, and materials science
The compound's structure and properties make it a useful tool in various scientific fields, including the study of biological processes, the development of new medical treatments, and the creation of advanced materials.

Future research and development

New and innovative applications in science and technology
Further investigation of 1-phenyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione may lead to the discovery of additional applications and uses in various scientific and technological areas.

Upstream product

• 412312-83-5 2-amino-3-(N-nitroso-anilino)-[1,4]naphthoquinone 
• 1090-16-0 2-chloro-3-(phenylamino)naphthalene-1,4-dione 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 622-37-7 Phenyl azide 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 90-15-3 α-naphthol 
• 7664-93-9 sulfuric acid 
• 7732-18-5 water 
• 130-15-4 [1,4]naphthoquinone 
• 137660-75-4 2-amino-3-(phenylamino)-1,4-naphthoquinone 
• 62-53-3 aniline 
• 113689-75-1 2-chloro-3-(N-nitroso-anilino)-[1,4]naphthoquinone 

Downstream Products

• 1600529-61-0 4,9-dioxo-3-methyl-1-phenylnaphtho[2,3-d][1,2,3]triazol-3-ium chloride 
• 1240215-61-5 2-[(1-phenyl-1H-1,2,3-triazol-4-yl)carbonyl]benzoic acid 

Relevant academic research and scientific papers

Small molecule compound having an IDO1/TDO double target, preparation method and applications thereof

The invention belongs to the field of chemical medicine, and particularly relates to a small molecule compound having an IDO1/TDO double target, wherein the general formula is defined in the specification. According to the present invention, the embodiment schemes prove that the small molecule compound can simultaneously inhibit two enzymes IDO1 and TDO so as to reduce the immune evasion of tumorcells, achieve self-cure of tumor diseases, achieve good medicinal potential and provides new potential choice for clinical medication; the preparation method has characteristics of simpleness, mild reaction condition, convenient operation, convenient control, low energy consumption, high yield and low cost, and is suitable for industrial production; and the prepared compound has advantages of high biological activity, strong selectivity to tumor cells, remarkable drug-like properties, and good application prospects in the pharmaceutical industry.

Metal-free cycloaddition to synthesize naphtho[2,3-d][1,2,3]triazole-4,9-diones

A metal-free domino [3 + 2] cycloaddition is reported to construct naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives and provide an alternative approach to the azide-alkyne cycloadditions. The key features are easily available starting materials, mild reaction conditions, a good atom economy, eco-friendly characteristics and a broad substrate scope with high yields.

A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents

Previously, we reported the synthesis and structure-activity relationship (SAR) study of a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-3-ium salts, which had very potent anti-proliferative activities (low μM to nM GI50

Synthesis of bioactive 1-alkyl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent

Through a [2+3] cycloaddition reaction, a new environmentally friendly method was developed to enable the synthesis of bioactive 1-alkyl-1H-naphtho[2, 3-d][1,2,3]triazole-4,9-diones and N-aryl-2-aminomethylene-1,3-indanediones using water as the solvent w

Synthesis and anticancer structure activity relationship investigation of cationic anthraquinone analogs

We have synthesized a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3- d][1,2,3]triazol-3-ium salts, which can be viewed as analogs of cationic anthraquinones. Unlike the similar analogs that we have reported previously, these compounds show relative