54660-06-9

Usage

Synthesis Reference(s)

Synthesis, p. 844, 1978 DOI: 10.1055/s-1978-24912

Upstream product

• 372-48-5 2-fluoropyridine 

Downstream Products

• 1391930-82-7 2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolidin-1-yl]pyridine 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 916518-48-4 2-phenyl-1-(pyridin-2-yl)pyrrolidine 

Relevant academic research and scientific papers

Magnesium-mediated arylation of amines via C-F bond activation of fluoroarenes

A series of new Mg(ii) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C-N bonds via nucleophilic substitution.

Cyclic AMP-specific phosphodiesterase inhibitors

Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.