54669-65-7

Upstream product

• 33553-23-0 2-phenacylcyclohexanone 
• 89-57-6 5-Aminosalicylic Acid 
• 1125-99-1 1-(1-Cyclohexen-1-yl)pyrrolidine 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 54670-07-4 2-hydroxy-5-(2-phenyl-indol-1-yl)-benzoic acid 
• 54670-22-3 1-(4-Acetoxy-3-carboxyphenyl)-2-phenyl-4,5,6,7-tetrahydroindole 
• 54670-01-8 1-(4-hydroxy-3-methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole 
• 54670-21-2 1-(3-Carboxy-4-methoxyphenyl)-2-phenyl-4,5,6,7-tetrahydroindole 
• 54669-71-5 2-mercapto-5-(2-phenyl-4,5,6,7-tetrahydro-indol-1-yl)-benzoic acid 
• 54670-02-9 1-(4-N,N-dimethylthiocarbamoyloxy-3-methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole 
• 54670-04-1 1-(4-N,N-dimethylcarbamoylthio-3-methoxycarbonylphenyl)-2-phenyl-4,5,6,7-tetrahydroindole 
• 54670-23-4 1-(4-Acetoxy-3-carboxyphenyl)-2-phenylindole 

Relevant academic research and scientific papers

Acid-catalyzed oxidative radical addition of ketones to olefins

Based on a mechanistic study, we have discovered a Bronsted acid catalyzed formation of ketone radicals. This is believed to proceed via thermally labile alkenyl peroxides formed in situ from ketones and hydroperoxides. The discovery could be utilized to develop a multicomponent radical addition of unactivated ketones and tert-butyl hydroperoxide to olefins. The resulting γ-peroxyketones are synthetically useful intermediates that can be further transformed into 1,4-diketones, homoaldol products, and alkyl ketones. A one-pot reaction yielding a pharmaceutically active pyrrole is also described.

Method of treatment with and compositions containing condensed pyrroles bearing an N-phenyl substituent

Novel N-phenylpyrroles are disclosed that are effective in the treatment of inflammation and pain in mammals and have the formula SPC1 Wherein R is hydrogen, alkyl of one to six carbon atoms, thienyl, phenyl or phenyl substituted by halogen, trifluorometh