54673-06-2Relevant academic research and scientific papers
Synthesis of non-natural flavanones and dihydrochalcones in metabolically engineered yeast
Werner, Sean R.,Chen, Hao,Jiang, Hanxiao,Morgan, John A.
body text, p. 257 - 263 (2010/11/18)
Flavonoids are plant phenolic compounds that have many interesting medicinal properties. Therefore, there is interestin the synthesisof non-natural flavonoidsas they may possess neworenhanced biological activities. In this study, metabolically engineered Saccharomyces cerevisiae expressing 4-coumaroyl:CoA-ligase (4CL) and chalcone synthase (CHS)was explored as a platform for producingnon-natural flavanones and dihydrochalcones. By precursor addition of cinnamic acid analogues to the engineered yeast, numerous non-natural flavanones and dihydrochalcones were formed in vivo. Also, several CHS derailment products were formed. Of the isolated compounds, one flavanone and three derailment products were found to be novel compounds.
