54674-84-9

Upstream product

• 603-35-0 triphenylphosphine 
• 627-30-5 1-chloro-3-hydroxypropane 

Downstream Products

• 791-28-6 Triphenylphosphine oxide 
• 1207945-69-4 (5E)-6-phenylhexa-3,5-dien-1-ol 
• 92587-78-5 trans-4-(p-methoxyphenyl)-3-buten-1-ol 
• 503817-58-1 diphenyl-3-tetrahydropyranyloxypropylphosphine oxide 
• 69768-97-4 (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol 
• 339079-71-9 (E/Z)-4-(4-methoxyphenyl)but-3-en-1-ol 
• 770-36-5 4-phenylbuta-3-en-1-ol 
• 889-57-6 3-(diphenylphosphinoyl)-1-propanol 

Relevant academic research and scientific papers

Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxy-phosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%.

Enantiospecific Synthesis of (-)-Tabtoxinine &β-Lactam

A convergent, 10-step synthesis of optically active tabtoxinine β-lactam has been described.Key features of the synthetic route include (1) preparation of a new γ-cation amino acid synthon, (-)-4, and its use as an electrophile (3 -> 11); (2) the one-pot conversion of methyl sulfide 11 to the Cbz-protected amine 12 via stereoselective sulfilimine rearrangement; and (3) chemoselective lactone ring opening in spiro lactam 15a.Synthons (-)-4 and 3 are available on a semipreparative scale.