54674-91-8

Upstream product

• 15174-69-3 4-hydroxy-3-methyl-benzaldehyde 
• 7451-94-7 4,6-bis(hydroxymethyl)-2-methylphenol 
• 14519-99-4 4-hydroxy-3-methyl-5-nitro-benzyl alcohol 
• 127-68-4 sodium 3-nitrobenzenesulfonate 

Downstream Products

• 528560-93-2 4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester 
• 1345840-14-3 C₁₅H₁₃N₃O₃ 
• 1345840-21-2 2-(4-methoxy-3-methyl-5-nitrophenyl)-1-methyl-1H-benzimidazole 
• 1345840-05-2 2-methyl-4-(1-methyl-1H-benzimidazol-2-yl)-6-nitrobenzenamine 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 
• 144701-48-4 telmisatran 
• 861792-67-8 4-methoxy-3-methyl-5-nitrobenzaldehyde 
• 1448812-25-6 5-((4-hydroxy-3-methyl-5-nitrobenzyl)amino)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile 
• 1448812-29-0 5-((3-amino-4-hydroxy-5-methylbenzyl)amino)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile hydrochloride 
• 1448812-17-6 N-(5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxy-3-methylphenyl)propionamide 
• 1246085-29-9 N-cyclopropyl-4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-3-methylbenzamide 
• 1246085-28-8 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethyl-3-methylbenzamide 
• 1246085-27-7 4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N,3-dimethylbenzamide 
• 1246085-31-3 3-chloro-N-cyclopropyl-4-(4-((2,8-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)benzamide 

Relevant academic research and scientific papers

The pyrazole derivative or its salt in a pharmaceutical composition containing them

PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.

Highly practical and cost-efficient synthesis of telmisartan: An antihypertensive drug

A novel and cost-efficient strategy for synthesis of an antihypertensive drug telmisartan, a substituted bis-benzimidazole derivative, is described. The key strategy is the construction of bis-benzimidazole 4 by reductive cyclization of o-nitroanilines 11 with butyl aldehyde and cyclocondensation of aromatic aldehydes 9 with o-phenylenediamine, then N-alkylation is allowed to give the target compound telmisartan after hydrolysis. The simple operation and workup procedure, along with the low production costs, make it suitable for industrial production and will benefits those with cardiovascular disease.