54679-39-9Relevant academic research and scientific papers
Facile construction of three-membered rings via benzyne-promoted Darzens-type reaction of tertiary amines
Xu, Ya-Nan,Tian, Shi-Kai
, p. 1632 - 1638 (2019)
A range of tertiary amines having electron-withdrawing groups were activated in situ by benzyne, generated from 2-(trimethylsilyl)phenyl triflate and a fluoride source, and participated in the Darzens-type reaction with carbonyl compounds, imines, and vinyl ketones to afford structurally diverse epoxides, aziridines, and cyclopropanes, respectively, in moderate to excellent yields with high trans-selectivity. The reaction involves in situ formation of unstrained ammonium ylides from tertiary amines and benzyne, proceeds in the absence of transition metals and strong bases, and tolerates a wide variety of functional groups.
β-alanine derivates
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Page/Page column 22, (2010/02/14)
Alkanoic acid derivatives of formula (1) are described: [in-line-formulae]Ar1(Alka)rL1Ar2CH(R1)C(Ra)(Ra′)R??(1)[/in-line-formulae]Ar1 is an optionally subst
