5468-46-2

Basic information

• Product Name: (2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid
• CAS NO: 5468-46-2
• Molecular Formula: C₁₀H₆N₂O₄
• Molecular Weight: 218.1656
• Mol File: 5468-46-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 421.9°C at 760 mmHg
• Flash Point: 209°C
• Density: 1.488g/cm³
• Vapor Pressure: 7.15E-08mmHg at 25°C
• Refractive Index: 1.668
• CAS DataBase Reference: (2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid(5468-46-2)
• EPA Substance Registry System: (2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid(5468-46-2)

Safety Data

• Hazardous Substances Data: 5468-46-2(Hazardous Substances Data)

Usage

General Description

(2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid is a compound with the chemical formula C11H8N2O4. It is also known as 2-cyano-3-(3-nitrophenyl)acrylic acid. This chemical is an unsaturated carboxylic acid and contains a cyanide group and a nitro group. It is commonly used as a starting material for the synthesis of various pharmaceuticals and agrochemicals. (2Z)-2-cyano-3-(3-nitrophenyl)prop-2-enoic acid has potential applications in the fields of medicine, agriculture, and chemical research. It is important to handle this chemical with care due to its potential toxicity and reactivity.

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 372-09-8 cyanoacetic acid 
• 14394-75-3 ethyl 2-cyano-3-(3-nitrophenyl)acrylate 

Downstream Products

• 123524-52-7 azelnidipine 
• 1242681-87-3 1,3-dimethyl-5-(3-nitrophenyl)-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidine-6-carbonitrile 

Relevant articles and documents

Preparation method of azelnidipine

The invention relates to a preparation method of azelnidipine, which comprises the following steps: carrying out Knoevenagel reaction on cyanoacetic acid and m-nitrobenzaldehyde used as starting materials to generate a compound 1; hydrolyzing cyano group of the compound 1 to generate a compound 2; carrying out esterification on the compound 2 and 1-diphenylmethyl-3-azetidin-ol under the action of DCC (N,N'-dicyclohexylcarbodiimide) to generate a compound 3; carrying out Hantzsch cyclization on the compound 3 and isopropyl 3-aminocrotonate under alkaline conditions to generate an azelnidipine crude product; and refining the crude product to obtain the azelnidipine fine product. The method is simple to operate and suitable for industrial production; and the reaction product is easy to separate.

Search for Potential Herbicides. Synthesis of Nitrophenyl-2-cyanoacrylamides

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