54680-38-5Relevant academic research and scientific papers
Nitrosation of 1-Substituted 3-(2-Pyridylmethyl)ureas and Related Compounds
Kamiya, Shozo,Sueyoshi, Shoko
, p. 1738 - 1742 (2007/10/02)
Nitrosation of 1-methyl- (Ia), 1-(2-chloroethyl)- (Ib) and 1-phenyl-3-(2-pyridylmethyl)urea (Id) with hydrochloric acid and sodium nitrite gave exclusively the corresponding 1-nitrosoureas (IIa,b,d).However, nitrosation of the 1-isopropylurea (Ic) gave a mixture of the 1-nitrosourea (IIc) and the 3-nitrosourea (IIIc).Similar results were also obtained in the nitrosation of 1-substituted 3-(2-pyridyl)ureas (Ie-h).The reaction of the nitrosoureas and m-chloroperbenzoic acid in chloroform gave the N-oxides (IVa-f, Vc,f,g), which were more stable than the nitrosoureas.Keywords-nitrosourea; 1-substituted 3-(2-pyridylmethyl)nitrosourea; 1-substituted 3-(2-pyridylethyl)nitrosourea; nitrosation; antitumor activity
