54698-36-1

Upstream product

• 694-54-2 tetrahydro-2H-2-pyranol 
• 98-59-9 p-toluenesulfonyl chloride 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 66120-17-0 7-hydroxy-trans-2-heptenoic acid 

Downstream Products

• 98206-48-5 [(1S,2S)-2-Cyano-2-(3-methoxy-phenyl)-cyclohexyl]-acetic acid 
• 98206-47-4 [(1S,2S)-2-Cyano-2-(3-methoxy-phenyl)-cyclohexyl]-acetic acid methyl ester 

Relevant academic research and scientific papers

The synthesis of carnosol derivatives

In this paper we report on the development of an efficient and flexible synthetic strategy towards the synthesis of carnosol type derivatives. The strategy involves the construction of the required trans-decalin structure with a carboxylic functionality in the angular position as well as the elaboration of the lactone ring to afford the tetracyclic core structure of the natural compound 1.