54699-91-1Relevant academic research and scientific papers
Isolation and identification of a new impurity in lorazepam substance
Cepanec,Mikuldas,Litvic,Vukusic
, p. 857 - 859 (2007/10/03)
A new impurity in lorazepam (1) was UV-detected during the HPLC-analysis of compound 1, batch scale. After the preparative chromatography on silica gel this impurity was isolated. According to IR, NMR, MS and elemental analysis the new impurity was identified as 7-chloro-5-(2-chlorophenyl)-2,3-dioxo-2,3,4,5-tetrahydro-1H-1,4- benzodiazepine (2).
