54699-97-7

Upstream product

• 69303-46-4 (6R)-3t-bromo-3c-methyl-5,5,8-trioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁶-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester 
• 69265-53-8 (6R)-3t-bromo-3c-methyl-5t,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester 
• 69265-57-2 (6R)-3t-bromo-3c-methyl-5c,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester 
• 55450-60-7 (6R)-3t-bromo-3c-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 4-nitro-benzyl ester 
• 69056-23-1 4-nitrobenzyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide 

Downstream Products

• 83901-07-9 (6R,7R)-3-Methyl-4-methylene-5,5,8-trioxo-7-(2-phenoxy-acetylamino)-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITIONS OF 2-METHYLENECEPHALOSPORINS

Cephalosporin R- and S-sulphoxides were prepared.The S-sulphoxides gave Mannich-reaction resulting in the formation of 2-methylenecephalosporins.These electrom-deficient dienes underwent 1,3-dipolar cycloadditions with diazoalkanes in a chemo- and regiosp