5470-49-5

Basic information

• Product Name: 4-Methylsulfonylaniline
• Synonyms: -(Methylsulfonyl)aniline;Benzenamine, 4-(methylsulfonyl)-;niline, p-(methylsulfonyl)-;4-(METHYLSULPHONYL)ANILINE;4-(METHYLSULFONYL)ANILINE;4-METHYLSULFONYL-BENZENEAMINE;4-mesylaniline;BENZENEAMINE, 4-METHYLSULFONYL-
• CAS NO: 5470-49-5
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• EINECS: 226-803-8
• Mol File: 5470-49-5.mol
• Article Data: 41

Chemical Properties

• Melting Point: 243-245°C
• Boiling Point: 384.3 °C at 760 mmHg
• Flash Point: 186.2 °C
• Appearance: White/Crystalline Powder
• Density: 1.44
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly, Sonicated), Ethyl Acetate (Slightly, Sonicated)
• PKA: pK1:1.48(+1) (25°C)
• Water Solubility: Soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 4-Methylsulfonylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylsulfonylaniline(5470-49-5)
• EPA Substance Registry System: 4-Methylsulfonylaniline(5470-49-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 22-24/25
• HazardClass: 6.1
• Hazardous Substances Data: 5470-49-5(Hazardous Substances Data)

Usage

Uses

It is used as pharmaceutical intermediate. A series of 4-(methylsulfonyl)aniline derivatives were synthesized in order to obtain new compounds as a potential anti-inflammatory agents with expected selectivity against COX-2 enzyme.

InChI:InChI=1/C7H9NO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,8H2,1H3

Upstream product

• 3466-32-8 4-bromoohenyl methyl sulfone 
• 104-96-1 4-methylsulfanylaniline 
• 1207-62-1 N-phenyl-N-(methylsulfonyl)methanesulfonamide 
• 187831-02-3 N-(4-acetylphenyl)-N-(methylsulfonyl)methanesulfonamide 
• 62-53-3 aniline 
• 1197-22-4 N-phenylmethanesulfonamide 
• 5317-89-5 4'-(methylsulfonylamino)acetophenone 
• 63-74-1 sulfanilamide 
• 74-88-4 methyl iodide 
• 20277-69-4 sodium methansulfinate 
• 106-47-8 4-chloro-aniline 
• 1849-36-1 para-nitrobenzenethiol 
• 100-00-5 4-chlorobenzonitrile 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 

Downstream Products

• 15863-56-6 1-isothiocyanato-4-methanesulfonyl-benzene 
• 177662-23-6 4-chloro-N-[4-(methylsulfonyl)phenyl]benzenecarboximidamide 
• 82964-91-8 4-methylsulfinylbenzenesulfonyl chloride 
• 1025831-84-8 [1-(2-Fluoro-phenyl)-meth-(E)-ylidene]-(4-methanesulfonyl-phenyl)-amine 
• 748801-83-4 4-methylsulfonyl-N-(4-methylbenzyliden)aniline 
• 850542-21-1 N-(4-methylsulfonylphenyl)-4-fluorobenzamide 
• 944915-39-3 C₂₂H₂₅N₃O₅S 
• 265113-49-3 5-(2,4-Difluorophenyl)-1-(4-methylsulfonylphenyl)imidazole(77 % yield) 
• 265113-59-5 5-(2-Fluoro-4-methoxyphenyl)-1-(4-methylsulfonylphenyl)imidazole(62 % yield) 
• 1027417-58-8 5-(4-fluoro-3-methoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-imidazole 
• 1025947-48-1 5-(3-chloro-4-ethoxy-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-imidazole 

Relevant articles and documents

COMPOSITES, METHODS AND USES THEREOF

The present invention relates, in general terms, to methods of catalysing a reaction, including the steps of contacting a chemical entity comprising a sulphide moiety with a composite and an oxidant. The composite acts as a heterogeneous catalyst to oxidise the sulphide moiety. The present invention also relates to composites, methods of synthesising the composites and its use as a catalyst thereof.

Method for catalytically oxidizing thioether to sulphone

The invention discloses a method for catalytically oxidizing thioether to sulphone. In this method, thioether is added to an ethanol solution. H2 O2 The nitrogen-nitrogen co-doped graphene catalyst is reacted at room temperature to obtain sulfone. The method is simple and convenient to operate, environment-friendly in reaction process, low in production cost, free of metal catalysts, free of secondary pollution, mild in reaction conditions, low in catalyst consumption, high and product yield and the like.

Cobalt Single-Atom-Intercalated Molybdenum Disulfide for Sulfide Oxidation with Exceptional Chemoselectivity

The identification of chemoselective oxidation process en route to fine chemicals and specialty chemicals is a long-standing pursuit in chemical synthesis. A vertically structured, cobalt single atom-intercalated molybdenum disulfide catalyst (Co1-in-MoS2) is developed for the chemoselective transformation of sulfides to sulfone derivatives. The single-atom encapsulation alters the electron structure of catalyst owing to confinement effect and strong metal–substrate interaction, thus enhancing adsorption of sulfides and chemoselective oxidation at the edge sites of MoS2 to achieve excellent yields of up to 99% for 34 examples. The synthetic scopes can be extended to sulfide-bearing alkenes, alkynes, aldehydes, ketones, boronic esters, and amines derivatives as a toolbox for the synthesis of high-value, multifunctional sulfones and late-stage functionalization of pharmaceuticals, e.g., Tamiflu. The synthetic utility of cobalt single atom-intercalated MoS2, together with its reusability, scalability, and simplified purification process, renders it promising for industrial productions.