54708-11-1

Basic information

• Product Name: N-(2,6-dimethylphenyl)oxazol-2-amine
• Synonyms: N-(2,6-dimethylphenyl)oxazol-2-amine
• CAS NO: 54708-11-1
• Molecular Weight: 188.229
• Mol File: 54708-11-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2,6-dimethylphenyl)oxazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,6-dimethylphenyl)oxazol-2-amine(54708-11-1)
• EPA Substance Registry System: N-(2,6-dimethylphenyl)oxazol-2-amine(54708-11-1)

Safety Data

• Hazardous Substances Data: 54708-11-1(Hazardous Substances Data)

Upstream product

• 4570-45-0 2-amino-1,3-oxazole 
• 6781-98-2 2,6-dimethyl-1-chlorobenzene 
• 2990-03-6 1-(2,6-dimethylphenyl)urea 
• 17157-48-1 bromoacetaldehyde 

Relevant articles and documents

Mechanistic Insight Leads to a Ligand Which Facilitates the Palladium-Catalyzed Formation of 2-(Hetero)Arylaminooxazoles and 4-(Hetero)Arylaminothiazoles

By using mechanistic insight, a new ligand (EPhos) for the palladium-catalyzed C?N cross-coupling between primary amines and aryl halides has been developed. Employing an isopropoxy group at the C3-position favors the C-bound isomer of the ligand-supported palladium(II) complexes and leads to significantly improved reactivity. The use of a catalyst system based on EPhos with NaOPh as a mild homogeneous base proved to be very effective in the formation of 4-arylaminothiazoles and highly functionalized 2-arylaminooxazoles. Previously, these were not readily accessible using palladium catalysis.