5471-97-6

Basic information

• Product Name: 1,3-diphenylpropane-1,3-diol
• Synonyms: (+-)-1,3-Diphenyl-1,3-propanediol; 1,3-Diphenyl-1,3-propanediol
• CAS NO: 5471-97-6
• Molecular Formula: C₁₅H₁₆O₂
• Molecular Weight: 228.2863
• Mol File: 5471-97-6.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 408.8°C at 760 mmHg
• Flash Point: 196.9°C
• Density: 1.164g/cm³
• Vapor Pressure: 2.04E-07mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: 1,3-diphenylpropane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-diphenylpropane-1,3-diol(5471-97-6)
• EPA Substance Registry System: 1,3-diphenylpropane-1,3-diol(5471-97-6)

Safety Data

• Hazardous Substances Data: 5471-97-6(Hazardous Substances Data)

Usage

General Description

1,3-diphenylpropane-1,3-diol, also known as truxilline, is a chemical compound that contains two phenyl (C6H5) groups and a diol (OH) group. 1,3-diphenylpropane-1,3-diol is often used in the synthesis of various pharmaceuticals and as a reagent in organic chemistry. It is a colorless crystalline solid that is insoluble in water but soluble in organic solvents. 1,3-diphenylpropane-1,3-diol is also used as a fragrance ingredient in perfumes and other personal care products due to its pleasant odor. It is important to handle this compound with caution, as it may be irritating to the skin and eyes if not handled properly.

Upstream product

• 94-41-7 benzalacetophenone 
• 100-52-7 benzaldehyde 
• 67210-34-8 1-phenyl-2-phenylsulfanyl-ethanol 
• 60-29-7 diethyl ether 
• 62961-62-0 (Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 1138-47-2 trans-1,2-diphenylcyclopropane 
• 98-86-2 acetophenone 
• 4192-77-2 ethyl cinnamate 
• 118356-60-8 3-(dimethyl(phenyl)silyl)-1,3-diphenylpropan-1-one 
• 64-17-5 ethanol 
• 7570-85-6 trans-2,3-epoxy-1,3-diphenyl-1-propanone 
• 120-46-7 1,3-diphenylpropanedione 
• 42052-51-7 3-hydroxy-1,3-diphenylpropan-1-one 

Downstream Products

• 19293-52-8 racemic 1,3-diphenyl-1,3-propanediamine 
• 135614-40-3 (1R,3R)-1,3-Diphenyl-N,N'-bis-[1-phenyl-meth-(E)-ylidene]-propane-1,3-diamine 
• 135613-89-7 (1R^*,3R^*)-N,N'-dibenzyl-1,3-diphenyl-1,3-propanediamine 
• 1454311-18-2 1,3-bis[(diphenylphosphino)oxy]-1,3-diphenylpropane 
• 107210-61-7 1,3-Diphenyl-3-((E)-3-phenyl-but-1-enyloxy)-propan-1-ol 

Relevant articles and documents

Reductive Ring-Opening 1,3-Difunctionalizations of Arylcyclopropanes with Sodium Metal

Sodium dispersion promotes reductive ring opening of arylcyclopropanes. The presence of a reduction-resistant electrophile, such as methoxypinacolatoborane, epoxide, oxetane, paraformaldehyde, or chlorotrimethylsilane, during the reductive ring opening event leads to the formation of 1,3-difunctionalized 1-arylalkanes by immediate trappings of the resulting two reactive carbanions. In particular, the ring-opening 1,3-diborylations of arylcyclopropanes afford 1,3-diborylalkanes with high syn selectivity.

Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts

Regio- and stereo-selective reduction of substituted 1,3-aryldiketones, investigated in the presence of different whole cell microorganisms, was found to afford β-hydroxyketones or 1,3-diols in very good yields (up to 95%) and enantiomeric excesses (up to 96%). The enantiomerically enriched aldols, obtained with the opposite stereo-preference by baker's yeast and Lactobacillus reuteri DSM 20016 bioreduction, could then be diastereoselectively transformed into optically active syn- or anti-1,3-diols by a careful choice of the chemical reducing agent (diastereomeric ratio up to 98 : 2). The latter, in turn, were stereospecifically cyclized into the corresponding oxetanes in 43-98% yields and in up to 94% ee, thereby giving a diverse selection of stereo-defined 2,4-disubstituted aryloxetanes.

Selective hydroformylation of various olefins using diphosphinite ligands

Novel diphosphinite ligands are synthesized by the reaction of various derivatives of 1,3-diols with chlorodiphenylphosphine. The synthesized ligands exhibited considerable impact on hydroformylation of various olefins with excellent regioselectivity toward branched aldehyde. The effect of solvent, temperature, pressure and catalyst loading on the hydroformylation reaction is also described. The synthesized diphosphinite ligands with rhodium precursor works under milder reaction conditions as compared to traditional phosphine and phosphite-based ligands. Copyright 2013 John Wiley & Sons, Ltd. A novel diphosphinite ligands are synthesized by the reaction of various derivatives of 1,3-diol with chlorodiphenylphosphine. The synthesized ligands exhibited a considerable impact on hydroformylation of various olefins with excellent regioselectivity toward branched aldehyde. The effect of solvent, temperature, pressure and catalyst loading on the hydroformylation reaction is also described. The synthesized diphosphinite ligands with Rhodium precursor works at milder reaction conditions as compared to traditional phosphine and phosphite based ligands. Copyright