54711-44-3Relevant academic research and scientific papers
Multicomponent Catalytic Enantioselective Synthesis of Isoxazolidin-5-Ones
Annibaletto, Julien,Martzel, Thomas,Levacher, Vincent,Oudeyer, Sylvain,Brière, Jean-Fran?ois
supporting information, p. 4447 - 4451 (2021/08/09)
We report herein a strategy to afford a multicomponent catalytic enantioselective synthesis of β-substituted isoxazolidin-5-ones via a KMC process promoted by a suited cupreine used as bifunctional organocatalyst. The hydroxamic acid component, with a ste
Formation of Complex Hydrazine Derivatives via Aza-Lossen Rearrangement
Polat, Dilan E.,Brzezinski, David D.,Beauchemin, André M.
supporting information, p. 4849 - 4852 (2019/06/27)
The development of a broadly applicable procedure for the aza-Lossen rearrangement is reported. This process converts amines into complex hydrazine derivatives in two steps under safe, mild conditions. This method allows the chemoselective formation of N-
Synthesis of N-Oxyureas by Substitution and Cope-Type Hydroamination Reactions Using O-Isocyanate Precursors
Allen, Meredith A.,Ivanovich, Ryan A.,Polat, Dilan E.,Beauchemin, André M.
supporting information, p. 6574 - 6577 (2017/12/26)
Oxy-carbamate O-isocyanate precursors facilitate access to synthetically valuable N-oxyureas via substitution with amines. This work exploits the reactivity of suitable O-isocyanate precursors, identified by a thorough study highlighting the different reactivity of isocyanate masking groups. This led to bench-stable O-isocyanate precursors, offering improved versatility in the synthesis of N-oxyureas, and demonstrates the controlled reactivity of masked O-isocyanates. Suitable precursors also enabled the first example of Cope-type hydroamination of unsaturated hydroxyureas.
