54716-27-7Relevant academic research and scientific papers
Synthesis and anticonvulsant evaluation of some new 2-substituted-3- arylpyrido[2,3-d]pyrimidinones
White, David C.,Greenwood, Thomas D.,Downey, Aaron L.,Bloomquist, Jeffrey R.,Wolfe, James F.
, p. 5711 - 5717 (2004)
A series of 2-substituted-3-arylpyrido[2,3-d]pyrimidinones was prepared for evaluation as potential anticonvulsants. In murine screening, compounds 4a-c having a 2-oxo-2-(4-pyridyl)ethyl group in the 2-position and a 2-substituted phenyl moiety at the 3-position of the pyridopyrimidinone system displayed the most potent anti-seizure activity in both the maximal electroshock (MES) and pentylenetetrazol (scPTZ) tests at doses in the 3-10 mg/kg range. Compound 4c showed no agonist activity at the GABAA receptor and was unable to block presynaptic sodium and calcium channels in vitro.
A Versatile One-Step Synthesis of 3-Aryl-2-styrylpyridopyrimidin-4(3H)-ones
Reddy, M. Satyanarayana,Ratnam, C. V.
, p. 977 - 979 (2007/10/02)
Condensation of 2-methylpyridooxazin-4(H)-one (I) with schiff bases (II) in acetic acid gives 3-aryl-2-styrylpyridopyrimidin-4(3H)-ones (III) in excellent yield.
