5472-36-6Relevant academic research and scientific papers
One-pot, solvent-free access to unsymmetrical ureas by palladium-catalysed reductive alkylation using molecular hydrogen
Mohy El Dine, Tharwat,Chapron, Simon,Duclos, Marie-Christine,Duguet, Nicolas,Popowycz, Florence,Lemaire, Marc
, p. 5445 - 5454 (2013/09/02)
Palladium-catalysed reductive alkylation of monosubstituted ureas has been studied in the presence of aldehydes and using molecular hydrogen as a clean reductant. Unsymmetrical N,N′-disubstituted ureas were formed in good to excellent isolated yields (60-93 %) without the production of salt waste. This reaction was incorporated to a one-pot, solvent-free sequence involving the alkylation of monosubstituted ureas generated in situ from the corresponding amines. Unsymmetrical N,N′-disubstituted ureas were prepared in 60-93 % isolated yield by palladium-catalysed reductive alkylation of monosubstituted ureas using aldehydes as alkylating agents and molecular hydrogen as a clean reductant. A one-pot, solvent-free sequence was also developed from the corresponding amines. Copyright
A simple conversion of amines into monosubstituted ureas in organic and aqueous solvents
Liu, Qi,Luedtke, Nathan W.,Tor, Yitzhak
, p. 1445 - 1447 (2007/10/03)
A versatile and highly efficient synthesis of monosubstituted ureas is described. The reaction of an amine with 4-nitrophenyl-N-benzylcarbamate, followed by hydrogenolysis, provides the corresponding urea in high yield and purity. This carbamate can also be employed for the derivatization of water-soluble polyamines (e.g. aminoglycoside antibiotics), while other reagents (e.g. benzylisocyanate) fail to give the desired products in any significant yield.
