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3'-Chloromethotrexate (3'-CMTX) is a chemical compound derived from methotrexate, an antifolate drug used in cancer treatment and autoimmune disease management. It is characterized by the presence of a chlorine atom at the 3' position of the methotrexate molecule, which modifies its chemical properties and potentially its therapeutic effects. 3'-CMTX has been studied for its ability to inhibit dihydrofolate reductase, a key enzyme in the synthesis of DNA and RNA, thereby disrupting the growth of rapidly dividing cells. This makes it a candidate for further research in the development of targeted therapies for various diseases.

5472-96-8

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5472-96-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5472-96-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,7 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5472-96:
(6*5)+(5*4)+(4*7)+(3*2)+(2*9)+(1*6)=108
108 % 10 = 8
So 5472-96-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H21ClN8O5/c1-29(8-10-7-24-17-15(25-10)16(22)27-20(23)28-17)13-4-2-9(6-11(13)21)18(32)26-12(19(33)34)3-5-14(30)31/h2,4,6-7,12H,3,5,8H2,1H3,(H,26,32)(H,30,31)(H,33,34)(H4,22,23,24,27,28)

5472-96-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Glutamic acid, N-[3-chloro-4-([(2,4-diamino-6-pteridinyl)methyl]-methylamino)benzoyl]-

1.2 Other means of identification

Product number -
Other names 3'-chloromethotrexate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5472-96-8 SDS

5472-96-8Downstream Products

5472-96-8Relevant academic research and scientific papers

Reactions of methotrexate with hypobromous acid and hypochlorous acid

Suzuki, Toshinori,Takeuchi, Rie

, p. 1250 - 1254 (2019/11/16)

Methotrexate is a folate antagonist cytotoxic drug employed in the therapy of cancers and rheumatoid arthritis. Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils at inflammation sites. The administered metho

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