5473-06-3

Usage

Heterocyclic compound

1H-Benzimidazole,5-methyl-2-propyl-(9CI) is a compound that contains a benzene ring fused to an imidazole ring.

Chemical applications

1H-Benzimidazole,5-methyl-2-propyl-(9CI) is used in various chemical applications due to its unique structure and reactivity.

Pharmaceutical applications

It has potential applications in drug development.

Chemical intermediate

It can be used as a chemical intermediate in organic synthesis.

Research and development

Its properties and uses make it an interesting target for further research and development in the field of chemistry and pharmaceuticals.

InChI:InChI=1/C11H14N2/c1-3-4-11-12-9-6-5-8(2)7-10(9)13-11/h5-7H,3-4H2,1-2H3,(H,12,13)

Upstream product

• 1104075-58-2 α-chlorobutylaldoxime O-methanesulfonate 
• 106-49-0 p-toluidine 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 107-92-6 butyric acid 
• 71-36-3 butan-1-ol 
• 614-83-5 2-bromo-4-methylacetanilide 
• 3020-81-3 butylamidine hydrochloride 
• 861534-82-9 butyric acid-(2-amino-4-methyl-anilide) 

Relevant academic research and scientific papers

Activated alumina ball catalyzed expeditious synthesis of 2-alkylbenzimidazoles with special emphasis on susceptible side chains possessing amide functionality

A solvent- and chromatography-free, non-hazardous green protocol for the synthesis of 2-alkylbenzimidazoles has been developed under neutral conditions with water as the only by-product. Activated alumina balls, which have been shown previously to assist in amidation reaction, also catalyze very successfully the condensation of benzene-1,2-diamines with carboxylic acids to produce the corresponding benzimidazoles. This methodology is also applicable to susceptible side chains possessing an amide functionality.

Ag-TiO2/clay composite photocatalyst for the oxidation-cyclization of 1,2-diamine compounds with propylene glycol or alcohols

Silver-loaded TiO2 (Ag-TiO2) and acidic clay (K10 montmorillonite) composite photocatalyst has been successfully applied for the light-induced conversion of o-phenylenediamine (OPD) and its derivatives to substituted benzimidazoles with various alcohols in acetonitrile using UV-A and solar light. The influence of the various photocatalysts, solvents, and substituents on the yield and selectivity of the products has been investigated. The mechanism of photocatalysis is proposed. Loading silver on TiO2 enhances product yield and selectivity both in UV and solar light. In the presence of primary alcohols, 2-aminothiophenol forms only disulfide and hence Ag-TiO2/ clay can be used as a green catalyst for the synthesis of disulfides.

Water-mediated synthesis of 2-substituted benzimidazoles by boric acid and glycerol

A very simple, mild, and highly efficient green catalyst has been developed for the synthesis of 2-substituted benzimidazoles by treatment of substituted ortho-phenylenediamines and aldehydes in water at 80C in the presence of boric acid (5 mol-%) and glycerol (0.05 mL). This methodology has been standardized on 55 substrates, and nine new compounds have been synthesized.

Synthesis of α-chloroaldoxime O-methanesulfonates and their use in the synthesis of functionalized benzimidazoles

Three different α-chloroaldoxime O-methanesulfonates were synthesized to investigate their chemical properties. The compounds were found to be stable and were able to be stored at ambient temperature without any precautions. The reactions with anilines we

Copper-catalyzed synthesis of benzimidazoles via cascade reactions of o-haloacetanilide derivatives with amidine hydrochlorides

(Chemical Equation Presented) We have developed an efficient method for the synthesis of benzimidazoles via cascade reactions of o-haloacetoanilide derivatives with amidine hydrochlorides. The protocol uses 10 mol % CuBr as the catalyst, CS2CO