54734-97-3

Upstream product

• 78366-89-9 [(2-Oxo-2-phenyl-ethyl)-phenyl-amino]-acetonitrile 
• 1504-16-1 3-phenyl-1H-indole 
• 870-24-6 2-chloroethanamine hydrochloride 
• 70-11-1 α-bromoacetophenone 
• 3009-97-0 N-phenylglycinonitrile 
• 54734-91-7 (3-phenyl-indol-1-yl)-acetonitrile 

Downstream Products

• 54735-05-6 1,10-diphenyl-3,4-dihydro-pyrazino[1,2-a]indole 
• 78367-08-5 1-Methyl-10-phenyl-3,4-dihydro-pyrazino[1,2-a]indole 
• 54735-00-1 1-(2-Benzoylaminoaethyl)-3-phenylindol 
• 78367-31-4 N-[2-(3-Phenyl-indol-1-yl)-ethyl]-acetamide 

Relevant academic research and scientific papers

Construction of pyrrole- and indole-fused CF3-piperazine derivatives

A series of pyrrole- and indole-fused trifluoromethyl-functionalized piperazine derivatives were constructed in moderate to good yields with excellent chemoselectivities via a Pictet-Spengler reaction under mild and operationally simple conditions. The synthetic utility of this protocol was further extended by the facile preparation of indole-fused CF3-1,4-diazocane and enantioenriched CF3-piperazines via a vinylogous Pictet-Spengler reaction and an asymmetric Pictet-Spengler reaction, respectively.

Synthesis of 10-Phenyl-3,4-dihydropyrazinoindoles and 3-Phenylindole-1-acetic Acids

3-Phenylindole-1-acetonitriles (IVa-e) have been prepared by a new method in which appropriate N-phenylglycinonitriles are condensed with phenacyl bromide and then the condensed products are cyclodehydrated with P2O5 in boiling xylene.Catalytic hydrogenat

Preparation of benzodiazepines

A 1-alkyl-1,2,4,5-tetrahydro-3H-1,4-benzodiazepine derivative is produced by contacting a 1-aminoethyl-indole derivative with a suitable oxidizing agent and then reducing the resulting 1-acyl-2,3-dihydro-1H-1,4-benzodiazepine derivative. The starting 1-am