54735-43-2Relevant academic research and scientific papers
In situ-generated zinc bromide-catalyzed α-bromination of alkanones in water
Juneja, Satinder K.,Choudhary, Deepak,Paul, Satya,Gupta, Rajive
, p. 2877 - 2881 (2006)
α-Bromination of alkanones with bromine catalyzed by in situ-generated zinc bromide from zinc dust and bromine in water is investigated. Bromination with dioxane-dibromide as a source of bromine does not require zinc dust and provides selectively α-mono and α,α-dibromo products in excellent yields when water is used as solvent. Copyright Taylor & Francis Group, LLC.
Reactions of ortho-substituted α,α-dibromoacetophenones with nucleophiles: first examples of combined carbophilic and bromophilic attack on C-Br bonds
Tatar, Jovana,Baranac-Stojanovi?, Marija,Stojanovi?, Milovan,Markovi?, Rade
scheme or table, p. 700 - 703 (2011/02/27)
An efficient method for the formation of α-carbonyl-monosubstituted acetophenones from ortho-methoxy- and ortho-hydroxy-α,α-dibromoacetophenones and a range of selected nucleophiles, occurring via a carbophilic substitution/bromophilic substitution/protonation cascade process, is described. In turn, the preparation of α,α-dibromoacetophenones, isolated in high yields, relies on the neighboring group participation of the ortho-substituents in the starting ortho-substituted acetophenones.
Regioselective bromination of organic substrates by tetrabutylammonium bromide promoted by V2O5-H2O2: An environmentally favorable synthetic protocol
Bora, Upasana,Bose, Gopal,Chaudhuri, Mihir K.,Dhar, Siddhartha S.,Gopinath, Rangam,Khan, Abu T.,Patel, Bhisma K.
, p. 247 - 249 (2007/10/03)
(matrix presented) Vanadium pentoxide very effectively promotes the bromination of organic substrates, including selective bromination of some aromatics, by tetrabutylammonium bromide in the presence of hydrogen peroxide; mild conditions, high selectivity, yield, and reaction rate, and redundancy of bromine and hydrobromic acid are some of the major advantages of the synthetic protocol.
