54752-50-0

Usage

Uses

Used in Organic Synthesis:
7-(TRIFLUOROMETHYL)-1-TETRALONE is utilized as a key building block in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a wide array of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 7-(TRIFLUOROMETHYL)-1-TETRALONE is employed as a pharmaceutical intermediate. Its unique structure and reactivity make it a promising candidate for the development of new drugs with potential therapeutic applications.
Used in the Synthesis of Bioactive Compounds:
7-(TRIFLUOROMETHYL)-1-TETRALONE serves as a precursor in the synthesis of various bioactive compounds, contributing to the advancement of pharmaceutical research and the discovery of new therapeutic agents.
Used in Drug Development:
The trifluoromethyl group present in 7-(TRIFLUOROMETHYL)-1-TETRALONE imparts specific physicochemical properties that are beneficial for drug development. This feature enhances the compound's potential to be incorporated into new drug candidates, improving their efficacy and pharmacokinetic profiles.

Upstream product

• 136295-01-7 4-(4-(trifluoromethyl)phenyl)butanoic acid 
• 145485-43-4 4-(3-(trifluoromethyl)phenyl)butanoic acid 

Relevant academic research and scientific papers

Synthesis of 1-tetralone derivatives using a Stille cross coupling/friedel crafts acylation sequence

An efficient method of synthesis of 1-tetralones has been achieved featuring a Stille cross-coupling reaction as the key step.

Synthesis of 1-tetralones by intramolecular Friedel-Crafts reaction of 4-arylbutyric acids using Lewis acid catalysts

Intramolecular Friedel-Crafts reaction of 4-arylbutyric acids efficiently proceeded in the presence of catalytic amounts of Lewis acids such as Bi(NTf2)3 and M(OTf)3 (M=Bi, Ga, In and rare-earth metals) to form 1-tetralones. Chroman-4-one and thiochroman-4-one were also obtained in good yields from 3-phenoxypropionic acid and 3-phenylthiopropionic acid, respectively.

Benzo-fused lactams that promote the release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.