54756-24-0Relevant academic research and scientific papers
Flavonoid epoxides. Part 20. Some unusual reactions of dimethyldioxirane (DMD) with flavonoid compounds
Burke, Anthony J.,O'Sullivan, W. Ivo
, p. 8491 - 8500 (2007/10/03)
Dimethyldioxirane (DMD), generally as a solution in acetone, has proved itself to be an excellent epoxidising agent. It was observed that either the 2'-hydroxychalcone epoxide or the tans-2,3-dihydroflavonol could be obtained depending on the pH of the reaction mixture and the type of β-arene ring present in the substrate. Using this methodology trans-2,3-dihydroflavonols can be synthesised in far better yields than by the most commonly used method for their synthesis, that of the Algar-Flynn-Oyamada reaction. Treatment of both flavonol 14 and the novel isoaurone 21 with DMD gave unusual products instead of the expected epoxides, but nonetheless, an epoxide was assumed to have formed during the reaction.
Copper(II)-catalysed Oxidation of Quercetin and 3-Hydroxyflavone
Utaka, Masanori,Takeda, Akira
, p. 1824 - 1826 (2007/10/02)
Quercetin and 3-hydroxyflavone are oxidized to the corresponding 2-alkoxyflavan-3,4-diones by CuCl2 catalysis in MeOH or EtOH under oxygen or nitrogen, the mechanism of which is proposed.
