54764-01-1

Basic information

• Product Name: 2-methyl-2,3-dihydroquinazolin-4(1H)-one
• Synonyms: 2-Methyl-2,3-dihydroquinazolin-4(1H)-one; 4(1H)-quinazolinone, 2,3-dihydro-2-methyl-
• CAS NO: 54764-01-1
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.1885
• Mol File: 54764-01-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 418.461°C at 760 mmHg
• Flash Point: 201.019°C
• Density: 1.12g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2-methyl-2,3-dihydroquinazolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2,3-dihydroquinazolin-4(1H)-one(54764-01-1)
• EPA Substance Registry System: 2-methyl-2,3-dihydroquinazolin-4(1H)-one(54764-01-1)

Safety Data

• Hazardous Substances Data: 54764-01-1(Hazardous Substances Data)

Upstream product

• 28144-70-9 anthranilic acid amide 
• 121-44-8 triethylamine 
• 75-07-0 acetaldehyde 

Downstream Products

• 1769-24-0 2-methyl-4-quinazolone 

Relevant articles and documents

The novel acid-base magnetic recyclable catalyst prepared through carbon disulfide trapping process: Applied for green, one-pot, and efficient synthesis of 2,3-dihydroquinazolin-4 (1H) -ones and bis(indolyl)methanes in large-scale

Herein, a nano acid-base catalyst using magnetic core and carbamodithioic acid functional group have been synthesized and characterized. Its efficiency in the synthesis of dihydroquinazolinones and bis(indolyl)methanes derivatives was investigated. This novel metal-free catalyst exhibited significant catalytic activity in both reactions under green and mild reaction conditions (the yield obtained for the first reaction products: 82–98 % and for the second one: 61–97 %). The catalyst displayed good recyclability with no significant loss of catalytic activity after eight runs (the conversion of the eighth run was found as 83 %, the fresh catalyst conversion was 95 %). The introduced approach is attractive due to its applicability in the large-scale synthesis of important medicinal compounds.

BF3-grafted Fe3O4@Sucrose nanoparticles as a highly-efficient acid catalyst for syntheses of Dihydroquinazolinones (DHQZs) and Bis 3-Indolyl Methanes (BIMs)

Current paper represents immobilization of sucrose on the Fe3O4 core and grafting of boron trifluoride (BF3) onto the new surface. The catalytic activity of these nanoparticles was tested in syntheses of Dihydroquinazolinones (DHQZs) and Bis (3-Indolyl) Methanes (BIMs) as two fruitful pharmaceutical structures. Acidic capacity, FT-IR, XRD, VSM, TGA and SEM–EDX tests are carried out on such novel nanoparticles (NPs). Catalyst has shown more acidic capacity per one gram of NPs than sulfonated homologue which was reported previously.

Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: Synthesis of natural products and drugs

A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.