54767-81-6

Basic information

• Product Name: 1-(3,4,5-TriMethoxyphenyl)oxirane
• Synonyms: 1-(3,4,5-TriMethoxyphenyl)oxirane
• CAS NO: 54767-81-6
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 211.2344
• Mol File: 54767-81-6.mol

Chemical Properties

• Melting Point: 54-55 °C
• Boiling Point: 127-129 °C(Press: 4-5 Torr)
• Appearance: /
• Density: 1.164±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(3,4,5-TriMethoxyphenyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4,5-TriMethoxyphenyl)oxirane(54767-81-6)
• EPA Substance Registry System: 1-(3,4,5-TriMethoxyphenyl)oxirane(54767-81-6)

Safety Data

• Hazardous Substances Data: 54767-81-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Medicinal Applications:
1-(3,4,5-TriMethoxyphenyl)oxirane is used as a reagent for the synthesis of biologically active compounds, contributing to the development of new drugs and therapies. Its unique structure and chemical reactivity make it a promising candidate for creating diverse organic compounds with specific properties and functionalities.
Used in Organic Synthesis:
1-(3,4,5-TriMethoxyphenyl)oxirane is used as a versatile building block in the synthesis of complex organic molecules, allowing for the creation of a wide range of compounds with various applications in different industries.
Used in Drug Development:
1-(3,4,5-TriMethoxyphenyl)oxirane is used as a scaffold for drug development, providing a foundation for the design and synthesis of new pharmaceuticals with potential therapeutic benefits.

Upstream product

• 6814-64-8 methylenedimethyl sulfurane 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 2181-42-2 trimethylsulphonium iodide 
• 75-18-3 dimethylsulfide 
• 77-78-1 dimethyl sulfate 
• 70775-39-2 dimethylsulfoxonium methylide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 51490-01-8 1-(3,4,5-trimethoxyphenyl)-2-bromoethanone 
• 2181-44-4 trimethylsulfonium methylsulfate 
• 134-96-3 syringic aldehyde 

Downstream Products

• 102104-68-7 3-<6-<2-hydroxy-2-(3,4,5-trimethoxyphenyl)ethylamino>hexyl>-1,3-thiazolidine 
• 5320-31-0 3,4,5-trimethoxyphenylacetaldehyde 
• 54767-83-8 1-(3,4,5-trimethoxyphenyl)-2-(tert-butylamino)ethanol, hydrochloride 
• 191671-18-8 2-methoxy-1-(3,4,5-trimethoxyphenyl)-1-ethanone 
• 1107692-36-3 (2R)-2-(3,4,5-trimethoxyphenyl)oxirane 
• 177472-80-9 (2S)-2-(3,4,5-trimethoxyphenyl)oxirane 
• 177329-69-0 (S)-1-(3,4,5-trimethoxyphenyl)-1,2-ethanediol 
• 1885-35-4 3,4,5-trimethoxybenzonitrile 
• 4838-96-4 N-methyl-3,4,5-trimethoxyphenethylamine 

Relevant articles and documents

Simple Syntheses of Marine Alkaloid, (+/-)-Chelonin A, and its Analogs

The first total synthesis of (+/-)-chelonin A and syntheses of its analogs are achieved based on 1-hydroxyindole chemistry.

Synthesis of 1-methoxyindoles and related analogs of pimprinine, (±)-chelonin A and B, based on 1-hydroxy-indole chemistry

The total synthesis of pimprinine, (±)-chelonin A and B, and their analogs are achieved based on 1-hydroxyindole chemistry.

Solvolysis, Electrochemistry, and Development of Synthetic Building Blocks from Sawdust

Either aldehyde or cinnamyl ether products can be selectively extracted from raw sawdust by controlling the temperature and pressure of a solvolysis reaction. These materials have been used as platform chemicals for the synthesis of 15 different synthetic substrates. The conversion of the initial sawdust-derived materials into electron-rich aryl substrates often requires the use of oxidation and reduction chemistry, and the role electrochemistry can play as a sustainable method for these transformations has been defined.

S-Methylidene agents: preparation of chiral non-racemic heterocycles

Reaction of sulfur ylide with aldehyde, imine, and ketone functionality affords the desired three-membered heterocycle in excellent yield. The sulfur ylide is generated in situ upon decarboxylation of carboxymethylsulfonium betaine functionality. Of the seven carboxymethylsulfonium betaine derivatives surveyed, the highest level of conversion of π-acceptor to heterocycle was obtained with the one having S-methyl and S-phenyl functionality bound to a thioacetate derivative. Methylene aziridinations and epoxidations involving the decarboxylation of carboxymethylsulfonium betaine functionality complements existing technologies with the advantages of the reaction protocol, levels of conversion, and scope. While moderate levels of diastereocontrol were observed in the aziridination of imine functionality, the four oxiranes resolved using Jacobsen's Co(II)-salen complex were obtained in both high yield and enantioselectivity. The isolated chiral non-racemic oxiranes constitute the formal synthesis of chelonin B and combretastatin starting from 3-bromo-4-methoxybenzaldehyde and 3,4,5-trimethoxybenzaldehyde, respectively.

Synthesis of some electron-rich aryl(hetaryl)oxiranes under phase-transfer and homogeneous conditions

Reactions of mono-, di-, and trimethoxybenzaldehydes with trimethylsulfonium methyl sulfate readily occur under mild homogeneous and heterogeneous phase-transfer conditions to give the corresponding aryloxiranes whose yields are comparable with those typi

Propenone derivatives

The present invention relates to propenone derivatives represented by the following formula (I): STR1 wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR5 (wherein Y represents S or O; and R5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R2 and R3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2 and R3 are combined to form substituted or unsubstituted methylene or ethylene; R4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.

PROPENONE DERIVATIVES

The present invention relates to propenone derivatives represented by the following formula (I): wherein R1represents substituted lower alkyl or YR5(wherein Y represents S or O, and R5represents substituted or unsubstitute

2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase

2,4-Diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear le

A Convenient Strategy for Homologation of p-Oxygenated Benzaldehydes

It is shown that p-oxygenated benzaldehydes can be conveniently obtained by pyrolysis of the corresponding oxiranes.