54768-73-9

Usage

Chemical Structure

It is a pyrimidine derivative with a chloro group ($Cl$) and a propyl group attached to the nitrogen atoms.

Functional Groups

Chloro group ($Cl$)
Propyl group ($C3H7$)

Application

Pharmaceutical Research and Drug Development: Utilized in the synthesis of potential antitumor and antiviral agents.

Mode of Action

Inhibition of Dihydrofolate Reductase (DHFR): It acts as a potential inhibitor of dihydrofolate reductase, an enzyme involved in nucleotide synthesis, making it a target for antitumor drugs.

Therapeutic Potential

Antitumor Activity: Investigated for its potential as an antitumor agent due to its ability to inhibit DHFR.
Antiviral Properties: Studied for potential antiviral effects.
Antimalarial Properties: Explored for its potential in combating malaria.

Biological Target

Dihydrofolate reductase (DHFR)

Research Areas

Pharmacology, Medicinal Chemistry

Overall Significance

An important chemical compound with promising therapeutic applications in oncology, virology, and infectious diseases.

Upstream product

• 107-10-8 propylamine 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 

Downstream Products

• 1612179-61-9 6-phenyl-4-N-propylpyrimidine-2,4-diamine 

Relevant academic research and scientific papers

An efficient and simple methodology for the synthesis of 2-amino-4-(N-alkyl/arylamino)-6-chloropyrimidines

In this study, twenty-nine 2-aminopyrimidine derivatives are synthesized in good to excellent yields by fusing 2-amino-4,6-dichloropyrimidine with different amines in the presence of triethylamine without using any solvent or catalyst. Nucleophilic substitution reactions of 2-amino-4,6-dichloropyrimidine with amines have also been performed in ethanol. Comparisons of the yields and reaction times for both solvent and solvent-free conditions have shown that the newly developed solvent-free protocol is high yielding, more efficient, and simpler compared to conventional methods.

MTH1 INHIBITORS FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS

A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

CHEMICAL COMPOUNDS

The invention is directed to to substituted indazole derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 - R6 and X are defined herein. The compounds of the invention are inhibitors of PDK1 and can be useful in the treatment of disorders characterized by constitutively activated ACG kinases such as cancer and more specifically leukemia and cancers of the breast, colon, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PDK1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Composition for slowing down the loss of hair based on pyrimidine N-oxides triaminosubstituted or their sulfoconjugated

Composition for slowing down the loss of hair and for inducing and stimulating its growth, comprising a compound of formula: STR1 in which: R1 and R2 denote H or an alkyl and do not simultaneously denote H; R3 and R4 denote H, an alkyl or a heterocyclic ring with the nitrogen in position 6 and do not simultaneously denote H; X denotes H or a halogen; Y denotes O or OSO3 ; and their addition salts of physiologically acceptable acids.