547742-07-4Relevant academic research and scientific papers
Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities
Jew, Sang-Sup,Park, Boon-Saeng,Lim, Doo-Yeon,Kim, Myoung Goo,Chung, In Kwon,Kim, Joo Hee,Hong, Chung Il,Kim, Joon-Kyum,Park, Hong-Jun,Lee, Jun-Hee,Park, Hyeung-Geun
, p. 609 - 612 (2003)
Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.
2 - SUBSTITUTED HETEROCYCLIC COMPOUNDS AND ANTITUMOR COMPOSITION COMPRISING THE SAME
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Page 9-10; 29, (2010/02/06)
The present invention relates with 2-substituted heterocyclic compounds and antitumor composition comprising the same. The compound according to the present invention exhibits superior effect as telomerase inhibitor based on new mechanism (terlomere-terlomerase) which can resolve the problems occurring at the time of using chemotherapeutics, i.e side effects and cross resistance between related mechanism on using chemotherapeutics. In addition, the antitumor composition comprising the compound of the present invention exhibits superior effect in inhibiting the growth of cancer cell.
