54780-57-3

Upstream product

• 84565-82-2 (1'S,5'S)-5'-Isopropenyl-2'-methyl-bicyclohexyl-2,5,2'-triene-1-carboxylic acid 
• 2244-16-8 (S)-p-mentha-6,8-dien-2-one 
• 7632-16-8 (2S,4S)-carveol 
• 57022-47-6 (4S,6S)-4-Isopropenyl-6-methoxy-1-methyl-cyclohexene 
• 98-80-6 phenylboronic acid 
• 84565-82-2 (S)-5'-Isopropenyl-2'-methyl-bicyclohexyl-2,5,2'-triene-1-carboxylic acid 
• 57022-47-6 carveol methyl ether 

Relevant academic research and scientific papers

Nickel-Catalyzed Arylation of C(sp3)-O Bonds in Allylic Alkyl Ethers with Organoboron Compounds

A nickel-catalyzed cross-coupling of allylic alkyl ethers with organoboron compounds through the cleavage of the inert C(sp3)-O(alkyl) bonds is described. Several types of allylic alkyl ethers can be coupled with various boronic acids or their derivatives to give the corresponding products in good to excellent yields with wide functional group tolerance and excellent regioselectivity. The gram-scale reaction and late-stage modification of biologically active compounds further prove the practicality of this synthetic method.

Hypervalent silane and siloxane derivatives and the use thereof

Hypervalent silane and siloxane reagents (preformed or generated in situ) for transmetalation in palladium catalyzed reactions with derivatives of allylic alcohols, aryl halides, electron-withdrawing aryl bromides, and aryl triflates derived from phenols are disclosed. Also disclosed are methods of preparing glycosyl azides by reaction of an azide with a silyl ester in the presence of a phoshine.

A HYBRID BIRCH-CLAISEN METHODOLOGY FOR ARYLATION AT ALLYLIC TERMINI: SYNTHESIS OF (+/-)-HERBERTENE

A hybrid Birch-Claisen methodology has been developed for the regio- and stereo-controlled arylation of allyl groups, and applied to a synthesis of (+/-)-herbertene.