54784-33-7

Usage

Uses

Used in Organic Synthesis:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-nitrosois used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for further functionalization and modification, enabling the synthesis of a wide range of organic molecules.
Used in Chemical Research:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-nitrososerves as a valuable research tool for chemists and researchers working in the fields of organic chemistry, medicinal chemistry, and materials science. Its properties and reactivity can be studied to gain insights into the behavior of similar compounds and to develop new synthetic methods and strategies.
Used in Pharmaceutical Industry:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-nitrosohas potential applications in the pharmaceutical industry for the development of new drugs. Its unique structure and properties can be leveraged to design and synthesize novel therapeutic agents with potential applications in various disease areas.
Used in Agrochemical Production:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-nitrosocan be utilized in the production of agrochemicals, such as pesticides and herbicides. Its reactivity and functional groups can be exploited to create new agrochemicals with improved efficacy and selectivity, contributing to more sustainable agricultural practices.
Used in Dye Production:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-5-nitrosocan also be used in the production of dyes, particularly those with specific color properties and stability. Its molecular structure allows for the development of dyes with unique characteristics, suitable for various applications in textiles, plastics, and other industries.

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 

Relevant academic research and scientific papers

Synthesis and evaluation of biological and antitumor activities of 5,7-dimethyl- oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives as novel inhibitors of FGFR1

A series of 5,7-dimethyl-oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives, N5a-5l, was designed, synthesized and evaluated for their FGFR1-inhibition ability as well as cytotoxicity against three cancer cell lines (H460, B16F10 and A549) in vitro. Several compounds displayed good-to-excellent potency against these cancer cell lines compared to SU5402. Structure-activity relationship analyses indicated that compounds with a rigid structure and more heteroatoms at the side chain of the parent ring were more effective than those without these substitutions. The compound N5g (37.4% FGFR1 inhibition at 1.0 μM) was identified to have the most potent antitumor activities, with IC50 values of 5.472, 4.260 and 5.837 μM against H460, B16F10 and A549 cell lines, respectively. Together, our results suggest that 5,7-dimethyl-oxazolo[5,4-d]pyrimidine-4,6(5H,7H)-dione derivatives may serve as potential agents for the treatment of FGFR1-mediated cancers.