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Z-A2bu(γPht)-OH, also known as Z-α-aminobutyryl-γ-phenylthiopropionic acid, is a synthetic peptide derivative characterized by its unique structure. It features a Z group (benzyloxycarbonyl) protecting the amino group, an α-aminobutyric acid (A2bu) as the central amino acid, and a γ-phenylthiopropionic acid (γPht) as the side chain. This chemical is often used in peptide synthesis and medicinal chemistry due to its potential applications in drug development, particularly in the design of inhibitors and other bioactive molecules. The γ-phenylthiopropionic acid moiety provides a hydrophobic and aromatic character, which can influence the compound's interaction with biological targets.

54786-05-9

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54786-05-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 54786-05-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,7,8 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 54786-05:
(7*5)+(6*4)+(5*7)+(4*8)+(3*6)+(2*0)+(1*5)=149
149 % 10 = 9
So 54786-05-9 is a valid CAS Registry Number.

54786-05-9Relevant academic research and scientific papers

THE SYNTHESIS OF A Nγ-PHTHALYL-Nα-METHYL-α,γ-DIAMINOBUTYRYL CONGENER OF VIRGINIAMYCIN S1

Anteunis, M. J. O.,Auwera, C. Van der,Vanfleteren, L.,Borremans, F.

, p. 135 - 148 (2007/10/02)

A synthesis of (A2bu=α,γ-diaminobutyric acid) is reported using the very efficient coupling agent BOP-Cl (N,N'-bis(3-oxo-2-oxazolidinyl)phosphinic chloride) for imino acid peptide bond formation.The total yield is 11percent for the 5 coupling steps and one lactonization.The final step was a cyclization between residues 5 and 6, after (I) first t-Boc acidic deprotection with 85percent HCOOH of the linear precursor Z-Thr(Nα-Boc-Phg-O-)-D-Abu-Pro-MePhe-MeA2bu(γPht)-OBut followed by (ii) acidic saponification (Tfa) of the t-Bu ester.This sequence was found to be prerequisite, in view of the extreme lability of the 4-5 peptide bond under acidic conditions.

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