548-04-9 Usage
Uses
Used in Pharmaceutical Industry:
Hypericin is used as an antidepressant agent for its ability to inhibit neuronal uptake of various neurotransmitters, leading to improved mood and reduced symptoms of depression.
Used in Antiviral Applications:
Hypericin is used as an antiviral agent for its in vitro activity against a variety of viruses, including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses. Its activity can be enhanced with photo-activation, making it a potential candidate for antiviral treatments.
Used in Anticancer Applications:
Hypericin is used as an anticancer agent for its broad-spectrum phototoxic effects, which involve the induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. This makes it a promising candidate for cancer treatment, particularly when combined with photo-activation.
Used in Analytical Chemistry:
Hypericin is used as a reference standard in determining hypericins in St. John's Wort using high-performance liquid chromatography (HPLC) methods. This helps in the accurate quantification and quality control of St. John's Wort extracts and products.
Hypericum perforatum extracts
Hypericin is an extract of Hypericum perforatum L.In 1957. It is first isolated from the Garcinia species Hypericum perforatum by human beings. Hypericin belongs to the bianthrone compounds, and it is the most biologically active substances. Hypericin is a yellowish brown to brown mobile powder, with slightly bitter taste. It is soluble in water, and can emit a special fragrance. It can inhibit the central nervous and has a sedative effect. Adding it to health care products can enhance immunity. It is also used as antidepressant drugs in Europe (especially in Germany). Hypericin also has a strong anti-viral effect, which can directly act on swine fever, foot and mouth disease and other viruses. In addition, it also has a good effect on killing highly pathogenic avian influenza virus.
Hypericum perforatum is one of the world's best-selling herbs in recent years, mainly containing hyperoside, quercetin, chlorogenic acid, caffeic acid, imanin, hypericin and other ingredients.
Hypericin is a few thousandths of the whole Hypericum perforatum. There are certain requirements for its extraction and testing. Methanol extraction method is common used in the past. Due to the toxicity of methanol, now the method is?? converted to use ethanol to obtain the active ingredient.
Indications
Hypericin is an anti-virus and pure Chinese medicine preparations. It is the first choice for the prevention and treatment of avian influenza drugs.
1, avian influenza, atypical Newcastle disease, infectious bronchitis, avian infectious laryngotracheitis , bursa of Fabricius, duck plague, duck viral hepatitis, egg drop syndrome and other viral diseases.
2, poultry fever caused by high fever, dyspnea, cough, head and face swelling, crown hair purple, lack of energy, decreased feed intake, egg drop, producing more abnormal eggs.
3, for classical swine fever, blue ear disease, parvovirus, viral enteritis, infectious gastroenteritis and immune dysfunction.
4, Hypericin has a strong anti-viral effect both in vivo and in vitro. It has a strong inhibitory effect on the early replication of HIV. Hypericin can lead to cancer cell programmed death, with anti-cancer effect. It has a enhanced immune function? for activating mononuclear phagocytic cells. In addition, it has a strong role in killing the highly pathogenic H5N1 and H9N2 subtype of avian influenza virus.
Biological Activity
Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
Biochem/physiol Actions
Primary TargetPKC
Purification Methods
Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]
References
1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233
2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775
Check Digit Verification of cas no
The CAS Registry Mumber 548-04-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 548-04:
(5*5)+(4*4)+(3*8)+(2*0)+(1*4)=69
69 % 10 = 9
So 548-04-9 is a valid CAS Registry Number.
InChI:InChI=1/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3
