548-82-3 Usage
Description
PINOBANKSIN, also known as rac-Pinobanksin, is a dihydroflavonol with potent antioxidant properties. It is a trihydroxyflavanone with three hydroxy substituents located at positions 3, 5, and 7. This bioflavonoid is predominantly found in propolis, a substance used by bees in the construction of their hives, and can also be found in honey.
Uses
Used in Antioxidant Applications:
PINOBANKSIN is used as an antioxidant agent for its ability to reduce lipid peroxidation. It plays a crucial role in protecting cells from oxidative stress and damage, which can lead to various diseases and aging.
Used in Pharmaceutical Research:
PINOBANKSIN is used as a reference material in the pharmaceutical industry for analytical studies of the presence and identity of anti-oxidative phenolic compounds found in plants such as propolis gum. This helps in the development of new drugs and therapies based on the antioxidant properties of PINOBANKSIN.
Used in the Honey Industry:
In the honey industry, PINOBANKSIN is used as an indicator of the quality and authenticity of honey. Its presence in honey signifies the presence of bioactive compounds derived from propolis, which contribute to the overall health benefits of honey.
Used in Cosmetics:
PINOBANKSIN may be used in the cosmetics industry for its antioxidant and anti-aging properties. It can be incorporated into skincare products to help protect the skin from environmental stressors and promote a youthful appearance.
Used in Analytical Chemistry:
PINOBANKSIN is used as a reference compound in analytical chemistry for the identification and quantification of phenolic compounds in various samples, including plant extracts and natural products. This aids in the quality control and standardization of these products.
Check Digit Verification of cas no
The CAS Registry Mumber 548-82-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 548-82:
(5*5)+(4*4)+(3*8)+(2*8)+(1*2)=83
83 % 10 = 3
So 548-82-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H12O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,14-17,19H/t14-,15+/m0/s1
548-82-3Relevant articles and documents
Stereospecific inhibition of nitric oxide production in macrophage cells by flavanonols: Synthesis and the structure-activity relationship
Jiang, Wen-Jun,Ishiuchi, Kan'Ichiro,Furukawa, Megumi,Takamiya, Tomoko,Kitanaka, Susumu,Iijima, Hiroshi
, p. 6922 - 6929 (2015/11/11)
To explore the structure-activity relationships on the inhibitory activity of flavanonols against nitric oxide (NO) production in inflammatory cells, we synthesized 19 flavanonols which shared a common 3,5,7-trihydroxychroman scaffold. A range of substitutions was included in the B ring in order to investigate the structure-activity relationship. We also succeeded in isolating stereoisomers from 16 of the flavanonols using chiral column chromatography. The inhibitory effects of these compounds on NO production were examined in RAW 264.7 cells (a murine macrophage-like cell line), which were activated by lipopolysaccharide (LPS). We only observed inhibitory activity against NO production in (2R,3R) stereoisomers, while the inhibitory activities of (2S,3S) stereoisomers were significantly weaker. We also evaluated the free radical scavenging potential of the flavanonols using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Each stereoisomer indicated the equivalent DPPH scavenging potential as expected. The radical scavenging activity was not correlated with the inhibitory activity against NO. The inhibition of NO production by flavanonols is stereospecific and cannot simply be explained by their radical scavenging activity. We propose the possible existence of a 'target' molecule for flavanonols which is involved in the production and/or regulation of NO in RAW 264.7 cells.