54807-10-2

Upstream product

• 75448-65-6 2-benzylidenehydrazino-4,6-bis(dimethylamino)-1,3,5-triazine 
• 10409-78-6 N²,N²,N⁴,N⁴-tetramethyl-2,4-diamino-6-hydrazinyl-[1,3,5]triazine 

Downstream Products

• 54807-00-0 5,7-bis(dimethylamino)-2-phenyl<1,2,4>triazolo<1,5-a><1,3,5>triazine 
• 91892-62-5 2-(3,5-Dinitro-phenyl)-N⁵,N⁵,N⁷,N⁷-tetramethyl-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine 

Relevant academic research and scientific papers

Triazines and Related Products. Part 26. Synthesis and Chemistry of Bicyclic Analogues of the Antitumour Drug 2,4,6-Tris(dimethylamino)-1,3,5-triazine (Hexamethylmelamine)

Interaction of 2,4-bis(dimethylamino)-6-hydrazino-1,3,5-triazine (1c) with aryl aldehydes yields a series of aryl hydrazones (4) which cyclise to 3-aryl-5,7-bis(dimethylamino)-1,2,4-triazolotriazines (6) with lead(VI) acetate in dichloromethane.Rearrangement of these bicycles in methanolic sodium hydroxide affords stable isomeric 2-aryl-5,7-bis(dimethylamino)triazolotriazines (7).Selected examples from both series of triazolotriazines were screened against the mouse M5076 reticulum cell sarcoma and P388 leukaemia in vivo but proved to have no antitumour activity.