54808-30-9

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 5908-27-0 potassium 1,2-naphthoquinone-4-sulphonate 
• 20513-06-8 2-amino-[1,4]naphthoquinone-4-imine 
• 13302-67-5 naphthalene-1,2,4-triol 
• 90-15-3 α-naphthol 

Downstream Products

• 74-90-8 hydrogen cyanide 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 63388-44-3 2-phenyl-4,9-dioxo-4,9-dihydro-naphtho[2,3-d]oxazole 

Relevant academic research and scientific papers

A new method for the synthesis of 2-hydroxy-3-nitro-1,4-naphthoquinones: Application to regiospecific preparation of unsymmetrical nitrobiquinones

Novel 2-hydroxy-3-nitro-1,4-naphthoquinones were synthesized by an improved method utilizing nitronium tetrafluoroborate in high yields. A subsequent conversion to 2-chloro-3-nitro-1,4-naphthoquinones and a substitution of the chlorine by hydroxyquinone anions yielded 3-nitro-2,2′-binaphthoquinones with a complete regiocontrol.

Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the

Compounds and methods for treating cancer

Provided are small molecule inhibitors of ubiquitin specific protease 2, 8 and 12 (USP2 and USP8 and USP12) activity and methods for their use in treating cancers. The small molecule inhibitors of the invention are particularly useful in the treatment of non-small cell lung cancers that are resistant to tyrosine kinase inhibitors and in the treatment of prostate cancer that is resistant to AR inhibitor therapy.

Synthesis and antiallergic activity of 2 hydroxy 3 nitro 1,4 naphthoquinones

A selection of novel 2-hydroxy-3-nitro-1,4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The most potent compounds were 7c and 7e which produced a 50% inhibition in the rat PCA test at doses of about 10 μM/kg following subcutaneous administration and showed activity after oral administration. Related 4-hydroxy-3-nitro-2(1H)-naphthalenones had no effect on rat PCA in doses up to 500 μM/kg.

2-Hydroxy-3-nitro-1,4-naphthoquinones

Substituted naphthoquinones of the formula (I) and pharmaceutically acceptable salts thereof wherein R1, R2, R3 and R4 represent alkyl, aryl, alkoxy, hydroxy, hydrogen or halogen or any two of the groups R1, R2, R3 and R4 taken together complete a carbocyclic ring, have useful anti-allergy activity in mammals.