54838-90-3Relevant academic research and scientific papers
Synthesis of 3,6-Dihydro-2 H-1,2-oxazines via Dimethylsulfoxonium Methylide Addition to α,β-Unsaturated Nitrones
Hasegawa, Megumi,Suga, Takuya,Soeta, Takahiro,Ukaji, Yutaka
, p. 11258 - 11264 (2020/10/12)
A unique and efficient formation of 3,6-dihydro-2H-1,2-oxazines starting from α,β-unsaturated nitrones has been achieved. The nucleophilic addition of dimethylsulfoxonium methylide to the C-N bond of an α,β-unsaturated nitrone to form an aziridine N-oxide followed by the Meisenheimer rearrangement affords 3,6-dihydro-2H-1,2-oxazine in up to 70% yield. Methylene was confirmed to be incorporated at the C3 position of the ring. A wide range of β-aryl-substituted α,β-unsaturated nitrones were applicable to this reaction.
