54840-14-1

Usage

Uses

Used in Organic Synthesis:
(4-HYDROXY-PHENYL)-CARBAMIC ACID PROP-2-YNYL ESTER is used as a key intermediate in organic synthesis for the creation of various complex organic molecules. Its unique structure allows for versatile reactions and the formation of a wide range of compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (4-HYDROXY-PHENYL)-CARBAMIC ACID PROP-2-YNYL ESTER is used as a precursor in the development of new drugs. Its chemical properties make it a valuable building block for the synthesis of potential therapeutic agents.
Used in Drug Development:
(4-HYDROXY-PHENYL)-CARBAMIC ACID PROP-2-YNYL ESTER is employed as a component in the formulation of biologically active compounds, which may have applications in treating various diseases and medical conditions. Its role in drug development is to contribute to the creation of innovative pharmaceuticals with improved efficacy and safety profiles.
Safety Considerations:
When handling (4-HYDROXY-PHENYL)-CARBAMIC ACID PROP-2-YNYL ESTER, it is essential to follow safety guidelines to mitigate any potential hazards associated with this chemical. This includes using appropriate personal protective equipment, working in well-ventilated areas, and disposing of the chemical according to regulatory standards to ensure the safety of both individuals and the environment.

Upstream product

• 35718-08-2 propargyl chloroformate 
• 123-30-8 4-amino-phenol 

Relevant academic research and scientific papers

Highly selective deblocking of propargyl carbonates in the presence of propargyl carbamates with tetrathiomolybdate

(Chemical Equation Presented) Propargyloxycarbonyl chloride, 1, has been used to protect the hydroxyl and amino functionalities of amino alcohols and aminophenols in one pot using triethylamine or pyridine as a base. The increased reactivity of benzyltriethylammonium tetrathiomolybdate, 2, toward propargyl carbonates over propargyl carbamates is studied in detail and has been exploited further to develop an orthogonal protection strategy for the hydroxyl and amino functionalities. For example, 2-amino-1-butanol, 6a, was treated with 1 to get the N,O-diPoc compound 7a in 90% yield, which when treated with 1.1 equiv of 2 at room temperature removes the Poc group attached to oxygen while leaving the one attached to nitrogen intact to yield compound 8a in 85% yield. This particular observation offers a new protecting strategy where an amine and an alcohol group can be protected simultaneously in one pot, and in a later synthetic step, if the alcohol group has to be deprotected selectively, it can be achieved with 1 equiv of 2.

Synthesis of potentially β-blocking practolol derivatives: (E + Z)-3- [4-(3-iodoprop-2-enyloxycarbonylamino)phenoxy]-1-(isopropylamino)propan-2-ol

The iodinatied carbamates 3 (E + Z), with potential β-blocking properties, were synthesized. The first route chosen, from 4-aminophenol and the chloroformate 7, had to be abandoned because of the formation of the oxazolidinone 10 during the epoxidation step. The aminoalcohol 17 prepared from the practolol 1 finally gave the target compounds by condensation with the iodoallylic chloroformates 8 (E + Z). The secondary Boc-protected amine function was regenerated without removing the carbamate function situated in the p-postion, by using mild reaction conditions (1 N HCl).

Ester of (alkynyloxy)-, (alkenyloxy)-, and (cyanoalkoxy) carbanilic acids and their use as herbicides

The invention is novel esters of (alkynyloxy)-, (alkenyloxy)-, and (cyanoalkoxy) carbanilic acids and the thiono and dithio derivatives of the carbanilic acids, and their use for controlling broadleaf weeds and grasses.