548436-62-0

Upstream product

• 586-96-9 Nitrosobenzene 
• 868-26-8 dimethyl 2-bromomalonate 
• 42937-74-6 dimethyl 2-(hydroxyimino)malonate 
• 98-80-6 phenylboronic acid 
• 3298-40-6 mesoxalate de methyle 

Downstream Products

• 548436-71-1 trimethyl 3-methoxalylindoline-2,2,3-tricarboxylate 
• 548436-91-5 dimethyl 4-ethoxycarbonyl-2,3-dihydro-2,5-diphenylisoxazole-3,3-dicarboxylate 
• 548436-75-5 trimethyl 2,3-dihydro-5-methyl-2-phenylisoxazole-3,3,4-tricarboxylate 
• 1024615-15-3 C₁₂H₁₄NO₅ 
• 1024615-20-0 C₁₃H₁₇NO₅ 
• 1374563-02-6 trimethyl 1-oxo-3-(4-tolyl)-1H-pyrrolo[1,2-a]quinoline-2,5,5-tricarboxylate 
• 1374563-06-0 trimethyl 3-(4-chlorophenyl)-1-oxo-1H-pyrrolo[1,2-a]quinoline-2,5,5-tricarboxylate 
• 1374562-91-0 tetramethyl 4-hydroxy-1-phenyl-3,6-dihydro-1H-pyridine-2,2,5,6-tetracarboxylate 
• 1374562-88-5 tetramethyl 2H-azeto[1,2-a]quinoline-1,1,3,4(4H)-tetracarboxylate 
• 1616487-66-1 2,2-dimethyl 4,5-dihydro-4-oxo-5-phenyl-1H-benzo[b]azepine-2,2(3H)-dicarboxylate 
• 1616487-69-4 2,2-dimethyl 4,5-dihydro-4-oxo-3-phenyl-1H-benzo[b]azepine-2,2(3H)-dicarboxylate 
• 1616487-72-9 2,2-dimethyl 4-oxo-1,5-diphenylpyrrolidine-2,2-dicarboxylate 

Relevant academic research and scientific papers

A highly efficient and stereoselective cycloaddition of nitrones to N-arylitaconimides

The 1,3-dipolar cycloaddition of keto- and aldonitrones with N-arylitaconimides proceeds regioselectively giving only 5-spiroisoxazolidines. In the case of aldonitrones the reaction proceeds with high diastereoselectivity. A range of the obtained adducts

Copper-Catalyzed Carbonyl Group Controlled Coupling of Isatin Oximes with Arylboronic Acids To Prepare N-Aryloxindole Nitrones

A variety of (E)-N-aryloxindole nitrones were prepared in good to excellent yields by using a copper-catalyzed coupling reaction of isatin oximes and arylboronic acids under mild conditions. Various arylboronic acids that contain sensitive functional groups were tolerated in the transformation, and detailed studies show that the carbonyl group of the isatin oximes serves as a ligand to control the formation of the (E)-oxindole nitrones. This method to prepare (E)-N-aryloxindole nitrones was easily performed on a gram scale and efficiently used to synthesize estrone-derived oxindole nitrone in high yield.

Highly efficient and stereoselective cycloaddition of nitrones to indolyl- and pyrrolylacrylates

The reactions of various nitrones with indolyl- and pyrrolylacrylates proceeds regioselectively with high diastereoselectivity in the case of aldonitrones, and represents an effective method for obtaining new indolyl- and pyrrolyl-substituted isoxazolidin

Synthesis and 1,3-dipolar cycloaddition reactions of N-aryl-C,C-dimethoxycarbonylnitrones

Arylnitroso compounds 1-3 easily reacted with dimethyl bromomalonate to give the corresponding N-aryl-C,C-dimethoxycarbonylnitrones (4-6). Treatment of C,C-dimethoxycarbonyl-N-(1-naphthyl)nitrone (4) with acetylene compounds (dimethyl acetylenedicarboxylate, methyl 2-butynoate or ethyl phenylpropiolate) caused 1,3-dipolar cycloaddition to furnish the corresponding 1H-benz[g]indolines (7a-c). In a similar manner, the reactions of nitrones 5 and 6 with acetylene compounds afforded the corresponding indolines 9a-c and 11a-c together with 4-oxazolines 13a-c and 14a-c.