548458-57-7

Upstream product

• 103-26-4 Methyl cinnamate 
• 96-22-0 pentan-3-one 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 133464-89-8 (Z)-(1-(benzyloxy)prop-1-enyloxy)trimethylsilane 

Downstream Products

• 548458-59-9 (2S)-2-benzyl-3-ethyl-3-hydroxypentanoic acid 

Relevant academic research and scientific papers

Catalytic enantioselective intermolecular reductive aldol reaction to ketones

We describe the first example of a catalytic enantioselective intermolecular reductive aldol reaction. Three types of reactions were studied: (1) reactions between acetophenone and methyl acrylate; (2) reactions between symmetric ketones and β-substituted

A new method for the catalytic aldol reaction to ketones

A new method for the catalytic aldol reaction to ketones, using CuF·3PPh3·2EtOH complex as the catalyst and (EtO)3SiF as the additive, is described. The reaction can be applied to a wide range of ketones and trimethylsilyl enolates. On the basis of mechanistic studies, a working hypothesis for the catalytic cycle is proposed, in which the dynamic ligand exchange mediated by copper silicates produces the active copper enolate. Moreover, the present reaction can be extended to the catalytic enantioselective reaction using tol-BINAP as a chiral ligand. Copyright