548462-64-2

Basic information

• Product Name: C₃₀H₄₂N₄O₅
• CAS NO: 548462-64-2
• Molecular Weight: 538.687
• Mol File: 548462-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₀H₄₂N₄O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₀H₄₂N₄O₅(548462-64-2)
• EPA Substance Registry System: C₃₀H₄₂N₄O₅(548462-64-2)

Safety Data

• Hazardous Substances Data: 548462-64-2(Hazardous Substances Data)

Upstream product

• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 
• 103127-52-2 ((S)-1-benzylallyl)carbamic acid tert-butyl ester 
• 19542-51-9 N-benzyloxycarbonyl-L-valyl-L-phenylalanine 
• 548462-56-2 C₃₆H₄₆N₄O₆ 
• 108-24-7 acetic anhydride 
• 548462-49-3 C₁₉H₃₀N₂O₄ 

Relevant articles and documents

New Cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines

The design and synthesis of hydroxyethylamine isosteres as inhibitors of cathepsin D based on SAR data have been accomplished. A library of 96 of these hydroxyethylamine isosteres are described and many have proven to be very potent inhibitors of human cathepsin D activity as measured using a fluorometric assay technique, via peptide substrate Ac-Glu-Glu(Edans)-Lys-Pro-Ile-Cys-Phe-Phe-Arg- Leu-Gly-Lys(Methyl Red)-Glu-NH2. Compounds showing strongest inhibition of cathepsin D activity were those that contain a hydroxyethyl-N'-2- or N'-(4-chlorophenyl)piperazine moiety (IC50 values range from 0.55 to 8.5 nM), with N'-(2-pyrimidyl)piperizine (IC50 values range from 0.5 to 21.6 nM), with NN'- L-piperazinocolinamide (IC50 values range from 0.001 - 0.25 nM), or N-N'-L-piperazinocolin-N-methylamide (IC50 values range from 0.015 - 7.3 nM) .