54848-77-0

Basic information

• Product Name: C₁₆H₁₆O
• CAS NO: 54848-77-0
• Molecular Weight: 224.302
• Mol File: 54848-77-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆O(54848-77-0)
• EPA Substance Registry System: C₁₆H₁₆O(54848-77-0)

Safety Data

• Hazardous Substances Data: 54848-77-0(Hazardous Substances Data)

Upstream product

• 116118-03-7 (E)-(3-methoxyprop-1-ene-1,3-diyl)dibenzene 

Relevant articles and documents

Base-Catalyzed Stereospecific Isomerization of Electron-Deficient Allylic Alcohols and Ethers through Ion-Pairing

A mild base-catalyzed strategy for the isomerization of allylic alcohols and allylic ethers has been developed. Experimental and computational investigations indicate that transition metal catalysts are not required when basic additives are present. As in the case of using transition metals under basic conditions, the isomerization catalyzed solely by base also follows a stereospecific pathway. The reaction is initiated by a rate-limiting deprotonation. Formation of an intimate ion pair between an allylic anion and the conjugate acid of the base results in efficient transfer of chirality. Through this mechanism, stereochemical information contained in the allylic alcohols is transferred to the ketone products. The stereospecific isomerization is also applicable for the first time to allylic ethers, yielding synthetically valuable enantioenriched (up to 97% ee) enol ethers.