548484-73-7Relevant academic research and scientific papers
Semi-synthesis of an O-glycosylated docetaxel analogue
Nikolakakis, Anastasia,Haidara, Khadidja,Sauriol, Francoise,Mamer, Orval,Zamir, Lolita O.
, p. 1551 - 1556 (2003)
A 7β-O-glycosylated docetaxel analogue was semi-synthesized from 9-dihydro-13-acetylbaccatin III, the most abundant taxane isolated from the needles of Taxus canadensis. It was shown to be more bioactive than paclitaxel according to the tubulin assay. It had a reduced potency in the MCF7 cell line cytotoxicity assay compared to paclitaxel, but it demonstrated better activity against the drug resistant cell line MCF7-ADR. In addition, the presence of one sugar moiety on C-7 doubled the water solubility versus that of paclitaxel.
