548488-25-1Relevant academic research and scientific papers
Synthesis, resolution and absolute configuration of trans 4,5-diphenyl-pyrrolidin-2-one: A possible chiral auxiliary
Escalante, Jaime,Gonzalez-Tototzin, Miguel A.
, p. 981 - 985 (2003)
β-Lactam (±)-N-benzyl-4-phenyl-azetidin-2-one rac-6a was converted into the γ-lactam (±)-trans-4,5-diphenyl-pyrrolidin-2-one rac-5 which was resolved via the preparation of diastereomers with N-phthalyl-L-alanine chloride or D-alanine chloride and its absolute configuration was determined by X-ray crystallographic analysis. This heterocycle has potential as a chiral γ-lactam in asymmetric induction due to the steric effects of its phenyl groups.
