54850-01-0

Basic information

• Product Name: 3,5-dichloro-2-hydroxy-benzoic acid p-anisidide
• Synonyms: 3,5-dichloro-2-hydroxy-benzoic acid p-anisidide
• CAS NO: 54850-01-0
• Molecular Weight: 312.152
• Mol File: 54850-01-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,5-dichloro-2-hydroxy-benzoic acid p-anisidide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dichloro-2-hydroxy-benzoic acid p-anisidide(54850-01-0)
• EPA Substance Registry System: 3,5-dichloro-2-hydroxy-benzoic acid p-anisidide(54850-01-0)

Safety Data

• Hazardous Substances Data: 54850-01-0(Hazardous Substances Data)

Upstream product

• 13340-60-8 phenyl-3,5-dichlorosalicylate 
• 104-94-9 4-methoxy-aniline 
• 3147-55-5 3,5-dibromosalicylic acid 
• 320-72-9 3,5-dichlorosalicylic acid 
• 39614-80-7 3,5-dichloro-2-hydroxy-benzoyl chloride 

Relevant articles and documents

Design, synthesis, and biological activities of closantel analogues: Structural promiscuity and its impact on onchocerca volvulus

Onchocerciasis, or river blindness, is a neglected tropical disease that affects more than 37 million people worldwide, primarily in Africa and Central and South America. We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific OvCHT1 inhibitor. Originally, closantel's anthelmintic mode of action was believed to rely solely on its role as a proton ionophore; thus, the impact of each of its biological activities on O. volvulus L3moltingwas investigated. Structure-activity relationship studies on an active closantel fragment are detailed, and remarkably, by use of a simple salicylanilide scaffold, compounds acting only as protonophores or chitinase inhibitors were identified. From these data, unexpected synergistic protonophore and chitinase inhibition activities have also been found to be critical for molting in O. volvulus L3 larvae.

Relationships between the chemical structure of antimycobacterial substances and their activity against atypical strains. Part 14: 3-Aryl-6,8-dihalogeno-2H-1,3-benzoxazine-2,4(3H)-diones)

A set of eight derivatives of 6,8-dichloro-3-phenyl-2H-benzoxazine-2,4(3H)-dione and nine derivatives of 6,8-dibromo-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dione, substituted on the phenyl ring, was prepared by the reaction of the corresponding salicylanilides with ethyl chloroformate. The compounds were evaluated in vitro for antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their activity increases with increasing hydrophobicity and electron-withdrawing ability of the substituents on the phenyl ring.