54856-61-0

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-5-chloronicotinaldehyde is used as a key intermediate for the preparation of benzopyrancarboxylates and quinolinecarboxylates. These compounds are known as cyclooxygenase-2 (COX-2) inhibitors, which play a significant role in reducing inflammation and pain. By targeting COX-2, these inhibitors can provide relief for conditions such as arthritis, menstrual cramps, and other inflammatory disorders without the side effects associated with non-selective COX inhibitors.
Additionally, 2-amino-5-chloronicotinaldehyde may be utilized in the development of other therapeutic agents, given its potential for further chemical modification and incorporation into more complex molecular structures. Its versatility as a building block in organic synthesis can lead to the discovery of novel drugs with improved efficacy and safety profiles.

InChI:InChI=1/C6H5ClN2O/c7-5-1-4(3-10)6(8)9-2-5/h1-3H,(H2,8,9)

Upstream product

• 116026-94-9 2--3-pyridinecarboxaldehyde 
• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 504-29-0 2-aminopyridine 
• 7521-41-7 2-Aminonicotinaldehyde 

Downstream Products

• 1441142-62-6 (2-amino-5-chloro-3-pyridyl)-[1-[4-chloro-3-(trifluoromethyl)phenyl]pyrazol-4-yl]methanol 

Relevant academic research and scientific papers

ARYLOXYACETYLINDOLES AND ANALOGS AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of aryloxyacetylindoles compounds and analogs useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds of general Formula (I) (I) or a pharmaceutically acceptable salt or prodrug thereof. Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a subject, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

An efficient synthesis of 2-amino-5-chloro-3-pyridinecarbox-aldehyde and 5-amino-2-chloro-4-pyridinecarboxaldehyde

Efficient synthetic routes to the title compounds 2-amino-5-chloro-3- pyridinecarboxaldehyde (1a) and 5-amino-2-chloro-4-pyridinecarboxaldehyde (1b) are reported. Both compounds are important substrates in the synthesis of naph-thyridine derivatives. Copyright by Walter de Gruyter Berlin Boston.

HERBICIDAL COUMPOUNDS

The present invention relates to novel herbicidal [l,8]-naphthyridines of Formula (Ia) or (Ib), or an agronomically acceptable salt of said compound wherein R2, R3, R4, R5,R6,R7, R8, n, m, X and Q are as defined herein. The invention further relates to processes and intermediates for the preparation of the [l,8]-naphthyridines, to compositions which comprise the herbicidal compounds, and to their use for controlling weeds, in particular in crops of useful plants.

Substituted benzopyran derivatives for the treatment of inflammation

A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.

Substituted benzopyran analogs for the treatment of inflammation

A class of benzopyrans, benzothiopyrans, dihydroquinolines, dihydronaphthalenes, and analogs thereof, is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I'wherein X, A1, A2, A3, A4, R, R'', R1 and R2 are as described in the specification.