54874-25-8Relevant academic research and scientific papers
Proximity- and chelation-induced SNAr 1,4-aromatic ortho-substitution of ortho-methoxyphenyl 2-alkyl ketones
Grelier, Gwendal,Chénard, Etienne,Büschleb, Martin,Hanessian, Stephen
, p. 1091 - 1100 (2015)
The direct displacement of an o-methoxy group in o-methoxyaryl ketones with aryl, alkyl, and alkenyl Grignard reagents to provide a series of o-substituted ketones is described. Application of this reaction to the synthesis of a C-methyl analogue of a cyc
