548757-40-0Relevant academic research and scientific papers
Phosphane-Catalyzed Knoevenagel Condensation: A Facile Synthesis of α-Cyanoacrylates and α-Cyanoacrylonitriles
Yadav, Jhillu S.,Subba Reddy, Basi V.,Basak, Ashok K.,Visali, Boddapati,Narsaiah, Akkirala Venkat,Nagaiah, Kommu
, p. 546 - 551 (2007/10/03)
Triphenylphosphane (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as ethyl cyanoacetate and malononitrile to afford substituted olefins. The reaction proceeds smoothly under mild and solvent-free conditions and the products are obtained in excellent yields with an E-geometry. This method is applicable for a wide range of aldehydes including aromatic, aliphatic and heterocyclic substrates. Microwave irradiation has been used to achieve enhanced reaction rates and improved yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
An eco-friendly synthesis of electrophilic alkenes catalyzed by dimethylaminopyridine under solvent-free conditions
Narsaiah, A. Venkat,Basak,Visali,Nagaiah
, p. 2893 - 2901 (2007/10/03)
Electrophilic olefins were synthesized in solvent-free condition using DMAP (10%mol) as catalyst in excellent yield and E-geometry. The various aldehydes which are aliphatic, aromatic, and heterocyclics underwent smoothly for Knoevenagel condensation with
Synthesis of N-protected cyano aziridines
Fioravanti, Stefania,Morreale, Alberto,Pellacani, Lucio,Tardella, Paolo A.
, p. 1083 - 1085 (2007/10/03)
A concise and inexpensive route to 2-cyano aziridine-2-carboxylates and 2,2-dicyano aziridines is reported by reaction of the easily obtainable corresponding α,β-unsaturated nitriles with sulfonyloxycarbamates in the presence of calcium oxide.
Organic Reactions in Ionic Liquids: Knoevenagel Condensation Catalyzed by Ethylenediammonium Diacetate
Su, Ce,Chen, Zhen-Chu,Zheng, Qin-Guo
, p. 555 - 559 (2007/10/03)
The moisture and air stable ionic liquids 1-butyl-3-methylimidazonium tetrafluoroborate [bmim]BF4 and 1-butyl-3-methylimidazonium hexafluorophosphate [bmim]PF6 were used as 'green' recycle alternatives to volatile organic solvents (VOCs) for ethylenediammonium diacetate (EDDA) catalyzed Knoevenagel condensation between aldehydes or ketones with active methylene compounds. Both aldehydes and ketones gave satisfactory results. The ionic liquids containing catalyst EDDA were recycled several times with no decrease in yields and reaction rates. In the case of 2-hydroxybenzaldehyde, the reactions led to the formation of 3-substituted coumarins under standard reaction conditions.
