548765-62-4Relevant academic research and scientific papers
Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects
Ebdrup, S?ren,Refsgaard, Hanne Hoffmann Fr?lund,Fledelius, Christian,Jacobsen, Poul
, p. 5449 - 5456 (2008/03/15)
Hormone-sensitive lipase (HSL) is an intracellular enzyme that has a central role in the regulation of fatty acid metabolism. The enzyme, therefore, is a potentially interesting pharmacological target for the treatment of insulin resistance and dyslipidem
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
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, (2008/06/13)
Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.
