548777-87-3Relevant academic research and scientific papers
The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2AAdenosine Receptor
Thomas, Ajiroghene,Buccioni, Michela,Dal Ben, Diego,Lambertucci, Catia,Marucci, Gabriella,Santinelli, Claudia,Spinaci, Andrea,Kachler, Sonja,Klotz, Karl-Norbert,Volpini, Rosaria
, p. 1829 - 1839 (2016/09/09)
The A2Aadenosine receptor (A2AAR) is a key target for the development of pharmacological tools for the treatment of central nervous system disorders. Previous works have demonstrated that the insertion of substituents at various posi
Synthesis and biological activity of trisubstituted adenines as A 2A adenosine receptor antagonists
Lambertucci, Catia,Vittori, Sauro,Mishra, Ram Chandra,Dal Ben, Diego,Klotz, Karl-Norbert,Volpini, Rosaria,Cristalli, Gloria
, p. 1443 - 1446 (2008/09/18)
The discovery of new drugs for the treatment of neurodegenerative disorders, such as Parkinson's disease, has become an attractive field of research. Due to the regulation of D2 receptor activity by A2 A adenosine receptor, potent and selective ligands of
A2A adenosine receptor antagonists
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, (2008/06/13)
Disclosed are novel A2A adenosine receptor antagonists, useful for treating various disease states, for example cardiovascular disorders, including tissue damage due to ischemia, CNS diseases, including Parkinson's disease, depression, and the
