548930-76-3Relevant academic research and scientific papers
Isothiazole ring formation with substituted 2-alkylthio-3-acyl-4-quinolinone using O-(mesitylenesulfonyl)hydroxylamine (MSH)
Choi, Jong Hee,Choi, Eun Bok,Pak, Chwang Siek
, p. 166 - 172 (2003)
Isothiazole ring skeleton was formed by the treatment of substituted 2-alkylthio-3-acyl-4-quinolinone with O-(mesitylenesulfonyl)hydroxylamine(MSH). A mixture of alkyl transferred 3-methyl-9-alkyl-4,9-dihydroisothiazolo[5,4-b]quinolin-4-one as a major product and dealkylated 3-methyl-4,9-dihydroisothiazolo[5,4-b]quinolin-4-one as a minor product was obtained from unsubstituted 2-alkylthio-3-acyl-4-quinolinone in the presence of K2CO3. When 2 equivalents of MSH were used in the absence of K2CO3 only dealkylated product was obtained in quantitative yield.
Metal-free visible light-promoted synthesis of isothiazoles: A catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions
Alemán, José,Berton, Mateo,Cabrera-Afonso, María Jesús,Cembellín, Sara,Halima-Salem, Adnane,Maestro, M. Carmen,Marzo, Leyre,Miloudi, Abdellah
, p. 6792 - 6797 (2020/11/09)
A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromenta
